Abdominal Malignant Tumors
Conditions
Interventions
Transcutaneous electrical stimulation of acupoints combined with esketamine group:30 minutes before anesthesia induction until the end of surgery (continuous stimulation), stimulate acupoints such as
Esketamine group:During anesthesia induction, administer 0.25 mg/kg of esketamine intravenously as a bolus, followed by an infusion at a rate of 0.125 mg/kg/h until the end of the surgery.
control group:Infuse an equal volume of normal saline according to the dosing regimen of the intraoperative ESK group. Infuse an equal volume of normal saline according to the dosing regimen of the in
Transcutaneous Electrical Acupoint Stimulation Group:Apply the TEAS device to stimulate acupoints such as Shenmen, Baihui, Neiguan, Hegu, Zusanli and Sanyinjiao 30 minutes before anesthesia induction
Sponsors
The First Affiliated Hospital of Bengbu Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age 18 - 80 years; planned to undergo radical surgery for abdominal malignant tumors (such as gastric cancer colorectal cancer liver cancer cholangiocarcinoma pancreatic cancer etc.) electively; assessed to be able to tolerate general anesthesia; anticipated surgical time = 1 hour; signed the informed consent form for the study.
Exclusion criteria
Exclusion criteria: Pre-existing mental abnormalities psychological disorders neuropsychiatric disorders or central nervous system disease history before surgery; those with cognitive dysfunction or unable to communicate; severe heart failure (NYHA IV) abnormal liver function (Child-Pugh C grade Annex 1) severe renal dysfunction (requiring dialysis before surgery) or ASA classification =IV; allergy to esketamine; contraindications for TEAS such as skin allergies infections itching or implanted pacemakers etc.; other conditions deemed inappropriate for participation in the study by the investigators or chief physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of depression one week after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain scores at rest/coughing 24 48 and 72 hours after surgery;Anxiety scores and incidence rates at 1 week 1 month and 3 months after surgery;Postoperative fatigue and quality of recovery on days 1 2 3 7 and 30 after surgery;Peripheral venous blood was collected before anesthesia induction (T0) 24 h after surgery (T1) 48 h after surgery (T2) and 72 h after surgery (T3) and the levels of serum BDNF and 5-HT were detected.;Depression scores and incidence rates at 1 and 3 months after surgery;Sleep quality on postoperative days 1 2 3 7 and 30; | — |
Countries
China
Contacts
Public ContactZhang Congli
The First Affiliated Hospital of Bengbu Medical University
Outcome results
None listed