Coronary heart disease
Conditions
Interventions
Healthy person group:The patients were randomly divided into experimental group and control group by two-stage crossover design, and the treatment was once. After a 2-week elution period, crossover w
group of acupoint external counterpulsation:Acupoint external counterpulsation
group of conventional external counterpulsation:Conventional external counterpulsation
Sponsors
Dongzhimen Hospital Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
30 Years to 85 Years
Inclusion criteria
Inclusion criteria: Healthy individuals: aged between 25 and 35 years old with a BMI of =18 and =25 kg/m2 regardless of gender. The subjects gave informed consent and voluntarily signed the informed consent form. Patient :(1) Gender is not limited and meets the diagnostic criteria for coronary heart disease; (2) More than one month after complete revascularization; (3) Mild to moderate patients with a GAD-7 or (and)PHQ-9 score of 5 to 14 points; (4) Age: 30 to 85 years old; (5) The subjects gave informed consent and voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: Healthy individuals :(1) Have any cardiovascular endocrine kidney or liver hematological immune system or infectious diseases; (2) Has received drug treatment within the past month; (3) Smokers and drinkers; (4) Exercise training was conducted one week before the start of the study; (5) There are contraindications for external counterpulsation. Patients :(1) Those with severe valvular heart disease obstructive cardiomyopathy or other non-ischemic heart diseases and grade IV cardiac function; (2) Those with a history of severe primary diseases of the liver kidneys nervous system and hematopoietic system as well as severe mental disorders; (3) Those at the stage of pregnancy or conception; (4) Patients who have used any anti-anxiety and/or antidepressant drugs within the past 3 months; (5) There are contraindications for external counterpulsation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale (HAMA) scores and Hamilton Depression Scale (HAMD) scores were recorded; | — |
Secondary
| Measure | Time frame |
|---|---|
| Parameters related to heart rate variability;Seattle Angina Questionnaire,SAQ;Cardiopulmonary exercise test related indicators;The changes of serum monoamine neurotransmitters were detected;Autonomic nerve function score;Non-invasive hemodynamic parameters;Targeted exosome protein antibody chip;Myokines related indicators;Pittsburghsleepqualityindex,PSQI;Non-targeted metabolomics;Related indicators of cognitive function; | — |
Countries
China
Contacts
Public ContactHan Xiaowan
Dongzhimen Hospital Beijing University of Chinese Medicine
Outcome results
None listed