Severe community-acquired pneumonia
Conditions
Interventions
Control group:Conventional Western medicine treatment including drug therapy (antibiotics corticosteroids etc.) if necessary mechanical ventilation support. On this basis, Wenyang Jiedu granule placeb
Treatment group:Conventional Western medicine treatment, including drug therapy (antibiotics, corticosteroids, etc.), if necessary, mechanical ventilation support. On this basis, Wenyang Jiedu granule
Sponsors
Guangdong Provincial Hospital of Chinese Medicine Dade Road General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) The diagnosis criteria of severe community-acquired pneumonia were met (2) Meet the diagnostic criteria of TCM diseases (3) Clear diagnosis of severe community-acquired pneumonia within 48 hours (4) Patients aged 18-80 years (5) Sign or authorize the signing of informed consent.
Exclusion criteria
Exclusion criteria: (1) APACHE II score >30 or SOFA score >12 (2) Septic shock occurs or the mean arterial pressure (MAP) remains 20mg prednisone daily or equivalent dose of glucocorticoids for 1 month or more before screening or cumulative >600mg prednisone equivalent dose of glucocorticoids for 1 month before screening) those undergoing transplantation and those infected with HIV (5) People who are allergic to multiple drugs and have a history of allergy to investigational drugs and their ingredients (6) Pregnant or lactating patients (7) Those who are participating in other drug clinical trials or have participated in other clinical trials within 1 month (8) Patients with enteral nutrition disorders or patients with clinical requirements for fasting
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical status improvement rate within 28 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU stay;Score on a 6-point scale;28-day case fatality rate;Inflammatory factor;Inflammatory blood count;PSI score;SOFA scoring;Day 28 Non-mechanical ventilation days;Length of stay;Inflammatory index;Evaluation of curative effect of traditional Chinese medicine; | — |
Countries
China
Contacts
Public ContactXi Xiaotu
Guangdong Provincial Hospital of Chinese Medicine Dade Road General Hospital
Outcome results
None listed