Coronary Heart Disease
Conditions
Interventions
Treatment group:The conventional Western medical treatment combined with Tanyu Tongzhi Capsule served
Control group:The conventional treatment regimen combined with placebo served
Sponsors
Zhejiang Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Presence of myocardial ischemia symptoms such as chest tightness and/or angina.2.History of percutaneous coronary intervention (PCI) =3 months prior with residual stenosis =50% in major coronary arteries (diameter >2.5 mm).3.Objective evidence of ischemia or microvascular dysfunction defined by at least one of the following:Dynamic ST-T segment changes on electrocardiogram(ECG);Abnormal myocardial perfusion on stress-rest cardiac single-photon emission computed tomography (SPECT);TIMI (Thrombolysis in Myocardial Infarction) flow grade 25;Microvascular resistance reserve (MRR) <2.1.4.Age 18–80 years (inclusive).5Provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1.Cardiovascular Comorbidities:Acute myocardial infarction (AMI) prior myocardial infarction coronary artery spasm dilated cardiomyopathy hypertrophic cardiomyopathy or hypertensive heart disease.2.Impaired Cardiac Function:Left ventricular ejection fraction (LVEF) 3× upper limit of normal [ULN]);Renal insufficiency (serum creatinine =265 µmol/L or eGFR <30 mL/min/1.73 m²);Pulmonary hypertension (mean PAP =25 mmHg);Chronic obstructive pulmonary disease (COPD) GOLD stage =3. 6.Hypersensitivity:Known or suspected hypersensitivity to Tanyu Tongzhi Capsule components;History of severe atopic reactions.7.Pregnancy/Lactation:Current pregnancy planned pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Seattle Angina Questionnaire (SAQ) Scores Across Time Points Compared to Baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of angina attacks;Canadian Cardiovascular Society (CCS) Classification of Angina Pectoris;Nitroglycerin dosage;Major Adverse Cardiovascular Events;Evaluation of Therapeutic Efficacy on TCM Syndromes; | — |
Countries
China
Contacts
Public ContactJinDai
Zhejiang Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed