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Study on the Safety and Efficacy of Low dose Neostigmine Injection into Zusanli for the Treatment of Gastrointestinal Dysfunction after Liver Transplantation

Study on the Safety and Efficacy of Low dose Neostigmine Injection into Zusanli for the Treatment of Gastrointestinal Dysfunction after Liver Transplantation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025000858
Enrollment
Unknown
Registered
2025-04-27
Start date
2022-01-01
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal dysfunction after liver transplantation

Interventions

Zusanli by neostigmine (Group B):Conventional management protocol +ST36 acupoint injection with neostigmine
Zusanli by normal saline (Group C):Conventional management protocol +ST36 acupoint injection with normal saline
Conventional treatment (Group A):Conventional management protocol 1) Gastrointestinal decompression: 2) Intestinal stimulation therapy
3) Prokinetic drug therapy: 4) Intestinal microbiota regulating agents

Sponsors

The Fifth Clinical School of Henan University of Traditional Chinese Medicine (Zhengzhou People's Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1) liver transplantation surgery whether orthotopic liver transplantation or split liver transplantation; 2) no bowel sounds on auscultation and 3) symptomatic bloating and distention.

Exclusion criteria

Exclusion criteria: 1) local infection at injection site; 2) history of intestinal obstruction and constipation; 3) signs of peritoneal irritation (abdominal tension and tenderness or rebound tenderness; 4) history of intractable constipation; 5) history of coronary artery disease epilepsy ventricular tachycardia asthma; and 6) Mental disorders which might interfere with their participation.

Design outcomes

Primary

MeasureTime frame
Recovery rate of gastrointestinal motility;

Secondary

MeasureTime frame
Time to first defecation;Time to first flatus;

Countries

China

Contacts

Public ContactWanghongyu

The Fifth Clinical School of Henan University of Traditional Chinese Medicine (Zhengzhou People's Hospital)

qinxingsong@126.com13526603016

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026