Asthma
Conditions
Interventions
Intervention Group:sequential syndrome differentiation-based Traditional Chinese Medicine therapy
Sponsors
Guangdong Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-80 years regardless of gender; (2) Diagnosed with bronchial asthma in the acute exacerbation phase (moderate to severe degree) ; (3) TCM syndrome differentiation confirming phlegm-damp obstructing the lung or phlegm-heat congesting the lung ; (4) Pulmonary function test showing PEF or FEV1=80% of predicted value; (5) Participants voluntarily join the study and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with other pulmonary diseases such as lung abscess pulmonary fibrosis active tuberculosis or bronchiectasis; (2) Patients with severe cardiovascular or cerebrovascular diseases including malignant arrhythmia unstable angina acute myocardial infarction cardiac function class III or above stroke or cerebral hemorrhage; (3) Patients with severe liver diseases (e.g. liver cirrhosis portal hypertension or bleeding due to esophageal/gastric varices) or severe kidney diseases (e.g. dialysis kidney transplantation); (4) Patients with malignant tumors or immunodeficiency disorders such as organ/bone marrow transplantation HIV infection or continuous use of immunosuppressants within the last 3 months; (5) Patients taking long term use of tonic diet of traditional Chinese medicine; (6) Patients unwilling to comply with study procedures or unable to cooperate due to psychiatric disorders; (7) Patients unable to complete pulmonary function tests; (8) Patients allergic or have a history of hypersensitivity reactions to the components of the investigational drugs; (9) Pregnant or planning pregnant of lactating women; (10) Patients participated in similar clinical trials one month before the screening period or currently participating in or planning to join other clinical trials during the study period; (11) Patients deemed by investigators to have poor compliance making follow-up difficult to complete.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peak Expiratory Flow(PEF); | — |
Secondary
| Measure | Time frame |
|---|---|
| Fractional exhaled nitric oxide(FeNO);pulmonary function test indexes;Asthma Control Test(ACT);Asthma Control Questionnaire(ACQ);Usage of the control and relieve medication;Clinical symptom score;the time of hospitalization or acute exacerbation;Computed Tomography(CT)scan;Acute exacerbation;Evaluation of airway mucus hypersecretion; | — |
Countries
China
Contacts
Public ContactLei Wu
Guangdong Traditional Chinese Medicine Hospital
Outcome results
None listed