glucolipid metabolic disorders
Conditions
Interventions
Sub-healthy people group:none
Glucolipid metabolism abnormal population group:none
Sponsors
The First Affiliated Hospital of Guangdong Pharmaceutical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Inclusion criteria of healthy population: According to the WHO definition health is a state of physical and mental fullness and good adaptability not just a state of absence of disease and frailty. At the same time they had not been diagnosed with any disease or had physical discomfort in the past 6 months. (2) Inclusion criteria of sub-health population: 1) aged 18–65 years; 2) physical symptoms such as fatigue sleep disturbance or pain; With depression or restless irritable or fear and timidity or short-term memory decline attention can not concentrate and other mental and psychological symptoms; Decreased frequency of interpersonal communication or interpersonal tension and other social adaptability. 3) Inclusion criteria of sub-health group with abnormal glucose and lipid metabolism and sub-health group without abnormal glucose and lipid metabolism: Based on the inclusion criteria of sub-health the patients with any one of the following 1-3 (or more) lasting for more than 3 months and excluding the diseases that may cause the following manifestations were classified as the abnormal glucose and lipid metabolism sub-health group. Those who did not have any of the following items (or more than one) for more than 3 months were classified as non-glucose and lipid metabolism abnormal sub-health group. 1. According to the diagnostic criteria of prediabetes "Expert Consensus on the intervention of prediabetes in Chinese Adults (2023 version)" issued by the Society of Endocrinology of the Chinese Medical Association predisease states with abnormal blood glucose but without clinical or subclinical diagnostic criteria for diabetes 6.1mmol/L= fasting blood glucose value 6.2 mmol/L and/or low density lipoprotein cholesterol >4.1 mmol/l and/or triglyceride =2.3 mmol/L and/or non-high density lipoprotein cholesterol >4.9mmol/L; 3. Nonalcoholic steatohepatitis or liver fibrosis or cirrhosis; 4. Presence of carotid or other atherosclerotic plaques.
Exclusion criteria
Exclusion criteria: Exclusion Criteria (1) Overall exclusion criteria 1) pregnant or lactating women; 2) suffering from communication disorders such as severe mental illness; 3) patients with malignant tumors; 4) complicated with serious heart liver kidney lung and other organ damage or hematopoietic system diseases. (2) Exclusion criteria for blood urine and stool collection: on the basis of the overall exclusion criteria 1) those who used antibiotics or immunosuppressants in the past month; 2) severe uncontrolled infection. (3) Exclusion criteria for tongue coating flora collection: on the basis of the overall exclusion criteria 1) patients with periodontal disease or severe gingivitis; 2) people wearing fixed orthodontic appliances or dentures; 3) people with the habit of using mouthwash daily; 4) those who used antibiotics or immunosuppressants in the past month; 5) smoking within 12 hours before sampling; 6) severe uncontrolled infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c;fasting blood sugar;Lipid complete; | — |
Secondary
| Measure | Time frame |
|---|---|
| High-sensitivity C-reactive protein;blood routine index;TCM Syndrome Scale of Glycolipid Metabolism;liver function;Diet and exercise;Imaging examination indicators;blood pressure;Tongue image in TCM;Eye image in TCM;Routine electrocardiogram;SF-36 scale;Pulse of TCM;kidney function; | — |
Countries
China
Contacts
Public ContactGuo Jiao
The First Affiliated Hospital of Guangdong Pharmaceutical University
Outcome results
None listed