recurrent oral ulcers
Conditions
Interventions
experimental group:Herbal gargle+Placebo granule
control group:Placebo gargle compound+pearl aphthous ulcer granules
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign informed consent before trial-related activities, be able to understand the procedure and method of the trial, and be willing to strictly follow the clinical trial protocol to complete the trial. 2. Age 18-75 years old, male or female. 3. It meets the classification and diagnosis criteria of recurrent oral ulcer, and the TCM syndrome type is aphthus-dampness-intrinsic syndrome. 4. No cancer or mental illness. 5. Antibiotics, painkillers, healing drugs, and other related therapeutic drugs have not been used in the past week, or the last medication has exceeded 7 half-lives subject to the elderly.
Exclusion criteria
Exclusion criteria: 1) Diagnosed as hand-foot-mouth disease, herpetic stomatitis, oral candidiasis, and other infectious diseases with similar clinical manifestations. 2) Oral ulcers caused by allergies and chemotherapy drugs. 3) Combined with other active oral periodontal and gingival diseases. 4) Patients with severe renal failure (creatinine exceeding 3 times the upper limit of normal) and liver function impairment (transaminase exceeding 5 times the upper limit of normal). 5) Fasting blood glucose =11.1mmol/L. 6) Allergic to various drugs in the program. 7) Pregnant and lactating women. 8) Researchers believe that poor adherence affects the evaluation of drug safety and efficacy as well as drug abusers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Canker ulcer pain index(painP);Mean ulcer healing time(timeT);the prolonged recurrence interval of ulcers(Recurrence timeRt);Ulcer lesion index(acreageA); | — |
Countries
China
Contacts
Public ContactLiping XU
The First Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed