Short stature
Conditions
Interventions
Sponsors
Jiangsu Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
3 Years to 14 Years
Inclusion criteria
Inclusion criteria: (1)Height below the 10th percentile for the same ethnicity age and gender (includes idiopathic short stature partial growth hormone deficiency recurrent respiratory infections functional dyspepsia etc.); (2)Children with height 5ug/L; (3)Open growth plates; (4)Height growth rate below the 25th percentile (-1SD) specifically: 1) 3-4.5 years old: <7cm/year (based on bone age) 2) 4.5 years old to puberty: <5cm/year (based on bone age) 3) Pubertal children: <6cm/year (based on bone age) without obvious chronic organic diseases; (5)Proportional stature; (6)Normal intellectual development. (7)Slow growth sparse yellow hair thin physique poor appetite pallid complexion loose stools flabby muscles pale tongue with thin white fur weak slow and forceless pulse. Presence of the main symptom of short stature and at least two other symptoms (including two). (8)Voluntary participation in the trial and signing of an informed consent form.
Exclusion criteria
Exclusion criteria: (1)Clearly diagnosed with systemic consumptive diseases or chronic diseases of the urinary system respiratory system blood system and endocrine system etc.; (2)Organic lesions of the central nervous system; (3)Combined chromosomal abnormalities; (4)Presence of bone metabolism abnormalities or history of medication that affects bone metabolism; (5)Allergic to the components of this medication; (6)Currently participating in other drug clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Predicted lifetime height change;Standard deviation of growth rate;Standard deviation of height; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chinese Medicine Symptom Score;RANKL;AP-1;CD8+;TGF-ß;FGFR;25-(OH)-VD;HMGB1;Faecal SCFA;VEGF;CD4+;BMP3;WNTS;Serum SCFA;Intestinal flora 16SrDNA sequencing;IGF-1; | — |
Countries
China
Contacts
Public ContactJin Ye
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed