osteoportic fracture
Conditions
Interventions
Without Osteoportic fracture:None
Fracture with abnormal BMD:None
Sponsors
Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1).Patients clinically diagnosed with fracture disorders (including but not limited to bilateral hips vertebral bodies forearms etc.) by orthopedic specialists according to ICD-10 diagnostic criteria; 2).Age = 18 years old; 3). Receiving standard perioperative therapeutic protocols and clinical management for fractures in hospital settings; 4).Individuals with cognitive competence to actively participate in research investigations examinations and adhere to follow-up schedules with written informed consent provided by the participant and/or legal guardian(s).
Exclusion criteria
Exclusion criteria: 1).Patients diagnosed with fractures of small joints in extremities or skull fractures by orthopedic specialists according to ICD-10 criteria; 2).Patients sustaining injuries from severe trauma (including but not limited to violent assaults suicidal falls) as documented in admission records; 3).Individuals with unstable vital signs impaired consciousness (Mini-MoCA score <12) or severe intractable pain precluding cooperation; 4).Cases of secondary osteoporosis (e.g. osteomalacia gout multiple myeloma) or severe endocrine comorbidities (including Cushings disease hypercalcemia hypercalciuria cardiorenal insufficiency); 5).Chronic concurrent users of medications affecting bone metabolism that cannot be discontinued; 6).Subjects with advanced deformities disabilities or loss of working capacity; 7).Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrent fracture death (cause of death time of death); | — |
Secondary
| Measure | Time frame |
|---|---|
| Bone metabolism index;Indexes of calcium and phosphorus metabolism;Bone mineral density;Metagenomic sequencing;Physical examination index;Targeting metabolomics;visual analogue scale;Blood routine index; | — |
Countries
China
Contacts
Public ContactYongjun Wang
Longhua hospital affiliated to Shanghai University of Traditional Chinese medicine
Outcome results
None listed