multiple myeloma
Conditions
Interventions
Blank control group:Do not take any treatment
Multiple myeloma patient group:Treat according to the actual situation
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for 1 MM patients: 1.1 Meet the Western diagnostic criteria for multiple myeloma; 1.2 Meet the traditional Chinese medicine standards for multiple myeloma with kidney deficiency and phlegm stasis syndrome; 1.3 Age = 18 years old and = 80 years old gender not limited; 1.4 Willing to accept this treatment plan and sign an informed consent form. Inclusion criteria for 2 blank control group patients: 2.1 Non multiple myeloma patients with abnormal blood count; 2.2 Age = 18 years old and = 80 years old gender not limited; 2.3 There is no history of infection or antibiotic use in the 4 weeks prior to blood collection.
Exclusion criteria
Exclusion criteria: Exclusion criteria for 1 MM patients: 1.1 Individuals with allergic constitution or allergies to relevant MM treatment drugs; 1.2 Severe heart disease including myocardial infarction and heart failure grade 3 or above; 1.3 Patients with severe liver and kidney dysfunction (ALT>5 * ULN GRF<15ml/min); 1.4 Other systemic diseases with clinical significance such as osteoporosis bone metastases and lumbar tuberculosis; 1.5 Patients with two or more complications such as bone disease infection bleeding anemia etc; 1.6 Individuals with alcoholism drug abuse mental disorders and intellectual disabilities; 1.7 Pregnant or lactating women. Exclusion criteria for patients in the blank control group: 2.1 Patients with pre-existing malignant tumors or immune related diseases; 2.2 Dysfunction of major organs such as the heart liver and kidneys; 2.3 Individuals with alcoholism drug abuse mental disorders and intellectual disabilities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ratio of CD3+T cells in bone marrow blood and peripheral blood; | — |
Secondary
| Measure | Time frame |
|---|---|
| Expression of PHF19 EZH2 H3K27me3;Number and proportion of T cell subsets in bone marrow and peripheral blood;Number and proportion of NK cell subsets in bone marrow and peripheral blood;Activation and killing function of NK cells in bone marrow and peripheral blood;Bone marrow and peripheral blood immune checkpoints as well as T cell depletion molecules; | — |
Countries
China
Contacts
Public Contacthailin chen
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine
Outcome results
None listed