Hypertensive heart failure
Conditions
Interventions
Test Group:Qishen Granules Hypertension optimization formula (QSGOF)
Control Group: Qishen Granules Hypertension optimization formula (QSGOF) placebo
Sponsors
Guang'anmen Hospital China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Meet the diagnostic criteria of hypertension and chronic heart failure and fulfill the criteria of left ventricular ejection fraction (LVEF) =40% and serum NT-proBNP level =450pg/ml; (2) Meet the criteria for the evidence of Toxic Evil Evidence of Heart Failure in Chinese medicine; 3)Age 18-75 years old gender is not limited; 4) NYHA class II-III; 5)Voluntary participation understanding and signing the informed consent.
Exclusion criteria
Exclusion criteria: 1) Acute stage of myocardial infarction (within 14 days); 2) Combined severe hepatic insufficiency (ALT>100U/L or AST>100U/L) severe renal insufficiency (glomerular filtration rate 5.5mmol/L or <3.5mmol/L); 3) Severe hematologic disease or malignancy; 4) Pregnancy or lactation; 5) Psychiatric patients; 6) Those with severe heart failure and life expectancy of less than six months; 7) Those who have taken Chinese medicine or proprietary Chinese medicine with similar function or components to the test drug within the last month; 8) Those who are known to have adverse reaction or allergy to the study drug; 9) those who participated in other drug clinical studies within 1 month before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy of treatment (defined as a reduction in NT-proBNP of more than 30%);Six-minute walk experiment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Failure Toxic Evidence Quantification Scale;Quantification of Heart Failure Symptom Grading Scale;Kansas City Quality of Life Scale for Cardiomyopathy Patients;Echocardiography-related indicators;NYHA Cardiac Function Classification; | — |
Countries
China
Contacts
Public ContactJun Li
Guang'anmen Hospital China Academy of Chinese Medical Sciences
Outcome results
None listed