Intracranial infection after neurosurgery
Conditions
Interventions
Prevention group of integrated Chinese and Western medicine:Chinese herbal medicine sequential therapy
Sponsors
Bei jing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 69 Years
Inclusion criteria
Inclusion criteria: (1) Admission to ICU immediately after neurosurgery, male or female, age 18 to 69 years old; and (2) Operation time >4 hours; Or postoperative cerebrospinal fluid leakage; Or postoperative placement of surgical area, external ventricular drainage, lumbar puncture drainage and other drainage tubes; Ventriculoperitoneal shunt; Or posterior fossa surgery; Or have a history of diabetes; Or craniocerebral injury and cerebral hemorrhage; Or on the morning of the first day after surgery, the patient had a conscious disorder, or had functional disorders such as expectoration and swallowing, or had artificial airways such as tracheal intubation and tracheotomy; and (3) Assessed patients with severe illness who are expected to remain in the ICU for more than 24 hours.
Exclusion criteria
Exclusion criteria: (1) Preoperative diagnosis of intracranial infection, pneumonia, bloodstream infection and other infections; (2) Have a history of severe allergy to antibiotics and Chinese medicine; (3) Patients with severe chronic organ dysfunction of the heart, lung, liver, kidney, or chronic health status score of 5 on the Acute Physiological and Chronic Health Score (APACHE II); (4) Deep coma, GCS 3 score, pupil dilation no light reaction, no breathing and other near-death symptoms
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary infection score(CPIS);Antibiotic dosage(DDD);APACHE II;Incidence of intracranial infection and pneumonia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine examination;temperature;hospitalization expenses;Glasgow prognosis score GOS;stool for routine;bacterial culture of CSF;renal function;fatality rate;Hepatic function; | — |
Countries
China
Contacts
Public ContactQiang Wang
Bei jing Tiantan Hospital, Capital Medical University
Outcome results
None listed