Mild Cognitive Impairment (MCI)
Conditions
Interventions
Combination:Acupuncture and adTMS
Stimulation group:adTMS + sham acupuncture
Sponsors
The second people's hospital of Nantong
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: [1] Age 50–80 years, meeting Petersen's MCI diagnostic criteria (MoCA score 18–25, MMSE =24); [2] MRI exclusion of structural lesions (cerebral infarction, tumor, post-hemorrhagic sequelae); [3] No history of epilepsy or intracranial metal implants; [4] Willing to sign informed consent and comply with TCM syndrome assessments and follow-up.
Exclusion criteria
Exclusion criteria: [1] Severe depression (HAMD =17) or other psychiatric disorders (e.g., schizophrenia); [2] Recent use (<4 weeks) of cholinesterase inhibitors, antidepressants, or immunomodulators; [3] Severe cardiac, hepatic, or renal dysfunction (Cr =2.0 mg/dL, ALT =3×ULN); [4] Intolerance to acupuncture or TMS (e.g., needle phobia, skin allergies).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA score change at 12 weeks; | — |
Secondary
| Measure | Time frame |
|---|---|
| MRS-NAA/Cr ratio ;P300 latency ;modified Barthel Index ; | — |
Countries
China
Contacts
Public ContactXia Jing
The second people's hospital of Nantong
Outcome results
None listed