Acute Radiation-Induced Esophagitis
Conditions
Interventions
Experimental Group:Jishi Shuanghua Granule
Sponsors
Leshan City Shizhong District Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Age between 18 and 75 years; 2) Pathologically confirmed non-small cell lung cancer, staged as III (according to the 8th edition of the American Joint Committee on Cancer standards); 3) Clinically assessed as unresectable and planned to undergo definitive concurrent chemoradiotherapy (CCRT); 4) Mean esophageal dose > 20 Gy; 5) Normal hematological, hepatic, and renal function; 6) Karnofsky Performance Status (KPS) score = 70.
Exclusion criteria
Exclusion criteria: 1) Previous history of thoracic radiotherapy; 2) Women who are pregnant or breastfeeding; 3) Inability to take oral medication adequately; 4) History of esophageal diseases, including but not limited to esophageal cancer, active reflux esophagitis, and esophageal reconstruction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grading of Acute Radiation Esophagitis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute Radiation Esophagitis-Related Pain Score;Short-term Efficacy of Lung Cancer Treatment (Disease Control Rate and Objective Response Rate);Quality of Life Score;Acute Radiation Esophagitis-Related Dysphagia Score;Long-term Efficacy of Lung Cancer Treatment (Progression-Free Survival and Overall Survival ); | — |
Countries
China
Contacts
Public ContactYuanyuan Zheng
Leshan City Shizhong District Cancer Hospital
Outcome results
None listed