schizophrenia
Conditions
Interventions
Group A:transcutaneous electrical acupoint stimulation plus transcutaneous auricular vagus nerve stimulation
Sponsors
Kunming Psychiatric Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosis of schizophrenia according to DSM-5 criteria; 2.Aged 18–65 years; 3.Stable for at least 4 weeks prior to enrolment; 4.Received a stable dose of antipsychotic medication (excluding patients on antidepressants) for at least 4 weeks prior to enrolment and remained unchanged during the study period; 5.PANSS-FSNS (N1blunted affect N2emotional withdrawal N3poor rapport N4passive/apathetic social withdrawal N6lack of spontaneity and flow of conversation G7motor retardation G16active social avoidance)= 24; 6.At least two core negative symptom items scoring = 4 (N1 N4 N6); 7.Agree and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.PANSS-FSPS (P1Delusions P3 Hallucinatory Behavior P5Grandiosity P6Suspicion/Persecution G9Unusual Thought Content) > 19; 2.Two or more items on the PANSS-FSPS with scores = 4; 3.Total score on the Calgary Depression Scale for Schizophrenia (CDSS) > 6; 4.Alcohol or substance dependence or addiction; 5.Commorbid psychiatric disorders such as depression anxiety obsessive-compulsive disorder bipolar disorder etc; 6.History of neurological disorders such as epilepsy or related conditions;7.Suicidal tendencies or violent behavior; 8.Severe physical diseases including severe cardiovascular disease liver disease kidney disease brain organic lesions etc; 9.Auricular malformations and other auricular disorders; 10.Devices that may affect or be affected by TEAS/taVNS such as pacemakers drug pumps cochlear implants or implanted brain stimulators; 11.Treatment site skin allergies infections etc; 12.History of TEAS or taVNS treatment within the past six months; 13.Females who are preparing for pregnancy pregnant breastfeeding or have a history of giving birth within 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PANSS-Factor Score for Negative Symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| SANS score;treatment response rate;wakefulness EEG and ECG;CDSS score;PANSS-Factor Score for Positive Symptoms;PANSS total score;PANSS-Factor Score for Negative Symptoms at other time points during the study;adverse event;compliance evaluation;CGI-S score; | — |
Countries
China
Contacts
Public ContactGong Yi
Kunming Psychiatric Hospital
Outcome results
None listed