Gastric cancer induced fatigue
Conditions
Interventions
Control group:Basic chemotherapy with placebo electroacupuncture intervention
Trial group:Basic chemotherapy with electroacupuncture intervention
Sponsors
Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated with Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Diagnosed by pathology as gastric cancer and meeting the CRF diagnostic criteria TNM staging is stages III-IV and TCM differentiation belongs to Qi deficiency and blood stasis syndrome; (2) Based on the pathological results and the patient's own condition specific platinum chemotherapy regimens will be applied and it is planned to receive at least 3 courses of chemotherapy regimens with a Piper fatigue score of = 4 points; (3) Age = 45 and = 80 years old regardless of gender; (4) Karnofsky score (KPS) = 60 points expected survival time greater than 3 months; (5) Clear consciousness and thinking able to correctly understand scale evaluation and independently complete scale filling; (6) Those who voluntarily participate in this experiment and sign an informed consent form with good compliance.
Exclusion criteria
Exclusion criteria: (1) At the time of enrollment other cancers or more severe primary diseases or bleeding tendencies of the heart brain liver kidney endocrine blood or neuropsychiatric systems were present; (2) Patients with major infectious diseases such as AIDS hepatitis B hepatitis C and syphilis; (3) Patients who have received Chinese medicine acupuncture and moxibustion and other relevant treatments or participated in clinical trials of other drugs 4 weeks before enrollment; (4) Patients with acupuncture and moxibustion allergy or psychological panic cannot cooperate with the treatment; (5) Alcohol or smoking addicts; (6) Pregnant or lactating women. (7) Patients who have previously received acupuncture treatment. (8) Patients with severe anxiety or depression. If any of the above conditions are met it will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Revised Piper Fatigue Scale-Chinese Version RPFS-CV; | — |
Secondary
| Measure | Time frame |
|---|---|
| nutritional indicator: ALB, PA, WBC, RBC, PLT, HB;Athens Insomnia Scale, AIS;Cancer Quality of Life Core QuestionnaireQLQ-C30;Hospital Anxiety and Depression Scales, HADS;Tumor markers: CEA, CA125, CA19-9;Inflammation indicators: IL-6, TNF-a, IL-1ß, IL-10, IFN-?, CRP, M-CSF;Symptom and signs score of Chinese Medicine;scRNA-seq with scATAC-seq; | — |
Countries
China
Contacts
Public ContactZhuang Xiaojun
Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated with Shanghai University of Traditional Chinese Medicine
Outcome results
None listed