Pump failure after primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction
Conditions
Interventions
experimental group:Conventional Western Medicine and Guanxinning Tablets treatment
control group:Conventional Western Medicine and Placebo treatment
Sponsors
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Meet the diagnostic criteria of STEMI and is in the acute phase (within 4 weeks of onset);2)Successful PCI with reperfusion therapy;3)Echocardiography:LVEF=50%;4)Killip classification: class II-III;5)Age range : 18-80 years old.
Exclusion criteria
Exclusion criteria: 1) Those who have taken experimental drugs other traditional Chinese medicines or traditional Chinese patent medicines within the last month;2) Those who are known to have adverse reactions to the investigational drugs;3) Those who are known to be allergic to the investigational drugs;4) Severe liver dysfunction (ALT>100U/L or AST>100U/L);5) Severe renal insufficiency (glomerular filtration rate<30ml/min);6) Hematological disorders and malignant tumors;7) Pregnancy or lactation period;8) Psychiatric patients;9) Uncontrollable hypertension or diabetes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction (LVEF Simpson's method); | — |
Secondary
| Measure | Time frame |
|---|---|
| NT-proBNP;Echocardiographic indices (LVEDD LVESD IVS LVPW FS E/e' E/A etc.);Twelve-lead electrocardiogram;electrolyte examination;Liver and kideny function;Routine urine tests;Minnesota Heart Failure Quality of Life Scale;6-minute walk test;Routine stool examination;Coagulation function;Macro-Micro Indicators in the Four-Dimensional Triangular Framework of Heart Failure;Chinese Medicine Symptoms and Signs;routine blood test;Adverse cardiovascular events;TCM symptoms and vital signs; | — |
Countries
China
Contacts
Public ContactZhao Xinjun
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
Outcome results
None listed