Allergic rhinitis
Conditions
Interventions
control group:Chlorpheniramine tablets 10mg/time, orally taken once a day for 14 days as a course of treatment, combined with placebo of Lu'e Biyan Formula (placebo is made by adding 5% positive drug
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age>18 years old and<60 years old; 2. Meet the diagnostic criteria of AR Western medicine; Severe or severe symptoms that have a significant impact on quality of life with symptoms occurring for more than 4 days per week and for = 4 consecutive weeks; The patient has at least three nasal symptoms (1) sneezing 2) watery nasal discharge 3) nasal itching 4) nasal congestion) and the daily average VAS score for each symptom is = 5 points; Or if there are 2 or more nasal symptoms (itching sneezing watery nose and nasal congestion) and at least one symptom scores = 2 points (on a four point scale); 3. Meet the traditional Chinese medicine syndrome differentiation criteria for nasal and lung qi deficiency and cold; 4. No history of asthma attacks or other allergic diseases within 3 months prior to enrollment; No use of glucocorticoids or antihistamines or leukotrienes within the week prior to enrollment; 5 voluntary signatories of informed consent form; 6. Patients who have not participated in AR clinical research in the past 3 months;
Exclusion criteria
Exclusion criteria: 1. Patients with combined rheumatic and autoimmune diseases; 2. Patients with nasal organic lesions such as sinusitis and nasal polyps bronchial asthma or other serious pulmonary complications; 3. Patients with combined tumors or severe impairment of heart liver kidney and other functions; 4. Those who are unable to cooperate due to mental illness or other reasons; 5. Pregnant or lactating individuals or those who have the ability to conceive and are unwilling/unable to take effective contraceptive measures; 6. History of smoking or drug abuse; 7. Those who have used local or systemic corticosteroids or other immunosuppressants in the past 3 months; 8. In the past week I have used mast cell membrane stabilizer anticholinergic drugs decongestants and other non drug treatments that have therapeutic effects on AR such as acupuncture and moxibustion and acupoint application; 9. Those who have used antihistamines and leukotrienes in the past week; 10. Those who have undergone nasal surgery within the past week; 11. Individuals with a history of allergies to the ingredients of the experimental drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptom scoring; | — |
Secondary
| Measure | Time frame |
|---|---|
| recurrence rate;Traditional Chinese Medicine Syndrome Score for Lung Qi Deficiency and Cold Syndrome;Quality of life score;Visual Analog Scale Score; | — |
Countries
China
Contacts
Public ContactJia Mingyue
China-Japan Friendship Hospital
Outcome results
None listed