Diminished ovarian reserve
Conditions
Interventions
acupuncture group:Acupuncture treatment
healthy control group:Only the baseline data were observed and recorded and no intervention was performed
Sponsors
Sir Run Run Shaw Hospital School of Medicine Zhejiang University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: DOR Group: 1)Age between 20 and 39 years. 2)Patients who meet the diagnostic criteria for DOR. DOR diagnosis follows the 2016 POSEIDON criteria and Delphi method-based Chinese experts opinions on diagnosis and treatment of assisted repro-ductive technology in low-prognosis patients 3)Anti-Müllerian hormone (AMH) < 1.2 ng/ml. 4)Antral follicle count (AFC) < 5 (Note: AFC should be measured on day 2-3 of the menstrual cycle with at least 4 weeks between two measurements). 5)Women with fertility desires planning for natural conception or who are assessed by a reproductive physician for a planned antagonist protocol in the next in vitro fertilization and embryo transfer (IVF) cycle. 6)Right-handed. 7)Willing to participate in the trial and sign informed consent. Healthy Control Group: 1)Age between 20 and 39 years. 2)Normal gynecological ultrasound normal hormone levels and normal menstrual cycle in terms of color amount and quality. 3)No severe heart liver kidney or hematologic system impairments. 4)Willing to participate in the trial and sign informed consent. 5)Right-handed. 6)Voluntary participation and informed consent.
Exclusion criteria
Exclusion criteria: 1)Coexisting conditions that affect fertility including congenital abnormalities of the reproductive organs untreated endometrial polyps untreated intrauterine infections untreated hydrosalpinx thin endometrium uterine fibroids endometriosis or other organic diseases. 2)Coexisting polycystic ovary syndrome (PCOS). 3)Coexisting untreated hyperprolactinemia hyperandrogenism thyroid dysfunction chronic adrenal insufficiency or other metabolic endocrine disorders. 4)Receiving acupuncture treatment related to fertility improvement within the past three months. 5)Plans for in vitro fertilization and embryo transfer (IVF-ET) within the next 2 months after enrollment. 6)Vulnerable populations other than illiterate individuals including those with mental disorders cognitive impairments critically ill patients pregnant women etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AFC; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-Rating Anxiety Scale;Self- Rating Scale of Sleep;Self-rating depression scale;AMH;follicle-stimulating hormone; | — |
Countries
China
Contacts
Public ContactFeng Gao
Sir Run Run Shaw Hospital School of Medicine Zhejiang University
Outcome results
None listed