cognitive impairment of cerebral small vessel disease
Conditions
Interventions
Control group:Guideline-based standardized internal medicine treatment
Treatment Group :Zishen Yizhi Wan
Sponsors
Hunan Provincia Hospital of Integrated Traditional Chinese and Western Medicine ( The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine)
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Age = 60 years; (2) Presence of cognitive impairment due to cerebral small vessel disease; (3) Meeting the diagnostic criteria for Yin Deficiency and Blood Stasis Syndrome according to Traditional Chinese Medicine (TCM) standards; (4) Voluntary participation in the trial and signing of the informed consent form by the patient or their legal representative.
Exclusion criteria
Exclusion criteria: (1) Presence of other neurological diseases leading to cognitive impairment such as Alzheimer's disease frontotemporal dementia Lewy body dementia Parkinson's disease multiple sclerosis traumatic brain injury autoimmune diseases or genetic disorders; (2) Presence of impaired consciousness unstable vital signs (e.g. blood pressure respiration heart rate) or severe cardiopulmonary diseases as determined by the investigator to be unsuitable for participation in this study; (3) Inability to understand and/or comply with study procedures and/or follow-up due to psychiatric disorders emotional disturbances or severe visual/auditory impairments; (4) Presence of severe liver kidney digestive system or hematopoietic system diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum Mental State Examination;Traditional Chinese Medicine Syndrome Score;Hopkins Verbal Learning Test;Hospital anxiety and depression scale;Vascular dementia assessment scale-cog;trail making test;Clock Drawing Test;neuropsychiatric inventory;Boston naming test-2;EuroQol Five Dimensions Questionnaire;Instrumental Activity of Daily Living; | — |
Countries
China
Contacts
Public ContactWu dahua
Hunan Provincia Hospital of Integrated Traditional Chinese and Western Medicine ( The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine)
Outcome results
None listed