Chronic Kidney Disease
Conditions
Interventions
control group: Integrated treatment of chronic kidney disease
treatment group:Yishen Xiezhuo enema prescription
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.35-65 years old; 2. Meet the diagnostic criteria of CKD3-5 (non-dialysis) that is eGFR<60[ml/(min·1.73m2)] and has not received kidney replacement treatment plans such as hemodialysis peritoneal dialysis and kidney transplantation; 3. The diagnosis of traditional Chinese medicine is in line with the syndrome of renal failure-spleen and kidney qi deficiency and stasis; 4. Stable blood pressure control and <160/100mmHg; 5. Diabetics use insulin to reduce sugar and stable blood sugar control; 6. Patients receive retention enema treatment with traditional Chinese medicine 7. Volunteer to sign an informed consent form before the trial-related activities be able to understand the procedures and methods of the test and be willing to strictly abide by the clinical trial plan to complete the test.
Exclusion criteria
Exclusion criteria: 1. They are receiving hormone non-steroidal anti-inflammatory drugs immunosuppressants phosphorus binders oral potassium-lowering drugs and other drugs; 2. Arrhythmia acute congestive heart failure AMI acute stroke unstable angina pectoris NYHA grade IV and above (New York Heart Association Cardiac Function Grading Standard); 3. Patients with acute infectious diseases chronic hepatitis B malignant tumor activity liver cirrhosis decompensation period hematopoietic system and other serious primary diseases various types of diabetes or abnormal glucose tolerance active tuberculosis or psychiatric patients; 4. The fluctuation range of eGFR is =30% within 3 months before joining the group; 5. Blood potassium is higher than the upper limit of the reference interval; severe metabolic acidosis; severe anemia Hb<70g/L. 6. Those who are allergic or intolerable to a certain drug in the study; 7. Pregnant or lactating patients; 8. Participating in other clinical trials or patients refuse to cooperat
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intestinal flora(species and abundance); | — |
Secondary
| Measure | Time frame |
|---|---|
| serum creatinine;Chinese medicine symptom complex score;The number of kidney transplant;glomerular filtration rate;serum inflammatory factors(IL-1ßIL-2IL-4IL-6IL-10);blood urea nitrogen;The number of deaths;The number of peritoneal dialysis;The number of hemodialysis; | — |
Countries
China
Contacts
Public ContactFan Zhenliang
Zhejiang Provincial Hospital of Chinese Medicine
Outcome results
None listed