Late-Onset Hypogonadism
Conditions
Interventions
Experimental group:Take Gulingji capsule (2 capsules/time once/day)
Control group:Placebo (2 capsules/time once/day)
Sponsors
Xiyuan Hospital China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
Male
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria of Western medicine for LOH (2) Conforming to the TCM syndrome differentiation standard of kidney-yang deficiency syndrome; (3) Male patients aged 40-70 years; (4) Total score of AMS questionnaire =27 (5) Voluntarily participate in this experiment and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Personal or family prostate or breast cancer patients; (2) Abnormal hematological or biochemical tests of clinical significance (anemia: hemoglobin less than 10 g/dL; Leukocytosis: leukocytes >10.0×109/L; Neutropenia: Neutrophils Absolute cell count 50%); (3) untreated endocrine diseases (hyperthyroidism or hypothyroidism Cushing syndrome etc.); (4) Diabetic patients with unstable blood glucose control fasting blood glucose = 1.5 times the upper limit of normal value or with diabetic complications (diabetic nephropathy peripheral neuropathy); (5) Patients with severe liver and kidney dysfunction defined as AST and/or ALT= normal values Limit 1.5 times; Creatinine and/or urea nitrogen = normal; (6) Patients with untreated severe sleep apnea syndrome; (7) Benign prostatic hyperplasia with severe lower urinary tract obstruction (IPSS>19 points); (8) Prostate-specific antigen (tPSA) higher than 4ng/ml; (9) History of heart failure angina pectoris myocardial infarction cerebrovascular accident and cerebral hemorrhage within the past 6 months; (10) Patients who have been treated with androgens or anabolic steroids in the past 3 months; (11) People who are allergic or allergic to known components of the test drug. Those who meet any of the above 11 criteria will meet the exclusion criteria and will not be included in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| aging mmales' symptoms scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Free testosterone;TCM syndrome score;Total cholesterol;international index of erectile function-5;triglyceride;Low density lipoprotein cholesterol;High density lipoprotein cholesterol;Serum testosterone; | — |
Countries
China
Contacts
Public ContactBin Yan
Xiyuan Hospital China Academy of Chinese Medical Sciences
Outcome results
None listed