Premature Ovarian Insufficiency
Conditions
Interventions
Western medicine treatment group:estrogen-progesterone sequential therapy
western medicine and Chinese medicine combined treatment group:Ningxin Tongyu Zishen Formula combined with estrogen-progesterone sequential therapy
Chinese medicine treatment group:Ningxin Tongyu Zishen Formula
Sponsors
The 3rd Affiliated Hospital Zhejiang Chinese Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 39 Years
Inclusion criteria
Inclusion criteria: (1) Female patients aged 18 to under 40 years; (2) Meet the diagnostic criteria for Primary Ovarian Insufficiency (POI): female patients under 40 years old with infrequent menstruation or amenorrhea for at least 4 months and FSH levels greater than 25 IU/L on two occasions spaced more than 4 weeks apart. (3) Voluntarily participate and sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Primary amenorrhea; (2) Various diseases affecting ovarian function such as chromosomal abnormalities thyroid or adrenal diseases chronic debilitating diseases malignant tumors nutritional metabolic diseases and severe malnutrition; (3) Individuals with liver or kidney dysfunction; (4) Uncontrolled and/or undiagnosed medical conditions that may interfere with or affect the study treatment such as severe liver heart kidney or brain diseases; (5) Individuals with severe mental illnesses who are unable to cooperate; (6) Individuals who have participated in other clinical trials within the last 3 months; (7) Individuals with allergic constitutions or allergies to the study medication; (8) Individuals who have not signed the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index;Six reproductive hormone routines;Total score of menstrual symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| improved Kupperman Score scale; | — |
Countries
China
Contacts
Public ContactYIzhou Zhang
Zhejiang Chinese Medical University
Outcome results
None listed