Precancerous lesions of the esophagus
Conditions
Interventions
Normal group:Endoscopic observation
High-grade intraepithelial neoplasia:Endoscopic observation
Pre and post verification queue:Endoscopic observation
Low grade intraepithelial neoplasia:Endoscopic observation
Sponsors
CHINA-JAPAN FRIENDSHIP HOSPITAL
Eligibility
Sex/Gender
All
Age
40 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1) Age 40-69 years old; 2) Generally in good condition ECOG score 0-2 points; 3) Esophageal squamous cell carcinoma high-risk screening population with pathological diagnosis of normal esophageal mucosa low-grade intraepithelial neoplasia or early esophageal cancer (including high-grade intraepithelial neoplasia); 4) Understand and agree to accept the relevant data and specimen collection of this project and sign the informed consent;
Exclusion criteria
Exclusion criteria: 1) Pregnant or lactating patients; 2) Patients with concurrent tumors in other parts organic diseases acute oral infections HBV or HCV diseases; 3) Patients with a history of diarrhea or infectious diseases within 4 weeks before collecting the microbiota; 4) Patients who have used antibiotics PPIs or other acid-suppressing drugs hormones or drugs related to regulating intestinal microbiota such as probiotics like Bifico within 4 weeks before collecting the microbiota; 5) Patients who have consumed foods or drugs that affect tongue color within 4 weeks before collecting the tongue image; 6) Patients with mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PBMC cell map, gene map and specific gene expression in peripheral blood;Metagenomic sequencing was used to detect oral microbial diversity, abundance and functional gene differences; | — |
Secondary
| Measure | Time frame |
|---|---|
| CCL2, IL-6, TNF-a, IFN-?, IL-17, G-CSF, CCL3, CXCL1, PAI-1, hEGF, 5-HT and other indicators;Hematoxylin-Eosin staining; | — |
Countries
China
Contacts
Public ContactJia Liqun
CHINA-JAPAN FRIENDSHIP HOSPITAL
Outcome results
None listed