Intestinal congestion reperfusion injury caused by hepatic blood flow occlusion during hepatobiliary surgery.
Conditions
Interventions
Test group:Wuda Granules + Conventional Treatment (Implement conventional treatment protocols, including antibiotic therapy, fluid replacement support therapy, and postoperative rapid rehabilitation n
Control group:Conventional treatment
Sponsors
Guangdong Proal Hosvincipital of Chinese Medicine Zhuhai
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Age between 18 and 70 years regardless of gender; 2) Cases scheduled for laparoscopic liver resection due to diagnoses such as hepatolithiasis or liver tumors; 3) Liver function classified as Child-Pugh A; 4) Intraoperative hepatic portal occlusion performed using the Pringle maneuver; 5) Preoperative electrogastrogram indicating normal gastrointestinal electrical activity; 6) Willingness to participate in the study and provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1) History of previous abdominal surgery; 2) Cases with combined dysfunction of major systemic or organ systems; 3) Patients with moderate to severe liver cirrhosis or moderate to severe portal hypertension; 4) History of gastrointestinal bleeding due to portal hypertension; 5) Family history of genetic diseases or cases with comorbid immune-related diseases; 6) Prior treatment with TACE PVE or radiotherapy before surgery; 7) Use of molecular targeted therapy chemotherapy or immunotherapy before surgery; 8) Cases unable to comply with taking the trial medication; 9) Contraindications to Wuda Granules such as spleen and stomach weakness pregnancy or allergies to drug components should be excluded; 10) Women who are breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Malondialdehyde; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Indicators (NRS Pain Score, Abdominal Distension Grade, Time to First Flatus, Time to Return of Normal Bowel Sounds);Laboratory Indicators (Complete Blood Count, Urinalysis, Liver and Kidney Function, Biochemical Indicators, Diamine Oxidase, IL-1ß, TNF-a); | — |
Countries
China
Contacts
Public ContactQiu Chengjiang
Guangdong Proal Hosvincipital of Chinese Medicine Zhuhai
Outcome results
None listed