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Evaluation of the therapeutic effect of Qi Jia Rou Gan Fang on liver fibrosis with Qi deficiency and collateral obstruction syndrome: a syndrome-specific proteomics based "disease-syndrome combination" evaluation model

Evaluation of the therapeutic effect of Qi Jia Rou Gan Fang on liver fibrosis with Qi deficiency and collateral obstruction syndrome: a syndrome-specific proteomics based "disease-syndrome combination" evaluation model

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025000443
Enrollment
Unknown
Registered
2025-02-28
Start date
2024-06-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver fibrosis

Interventions

Western medicine control group:Entecavir Tablets
treatment group:Qi Jia Rou Gan Fang+ Entecavir Tablets
Healthy control group:no

Sponsors

Chengdu Public Health Clinical Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria of chronic hepatitis B liver fibrosis;2.Meet the diagnostic criteria of Chinese medicine qi deficiency and collateral blockage; 3.Age between 18-70 years old; 4. Good compliance and signing the informed consent.

Exclusion criteria

Exclusion criteria: 1.those who do not meet the inclusion criteria;2. those with poor compliance;3. those who are participating in other research projects;4.those who are diagnosed with chronic hepatitis B of severe type or have a tendency to severe hepatitis etc.;5.those with other types of hepatitis such as alcoholic drug-induced and other viral liver diseases;6. those with posthepatitis decompensated stage;7. those who suffer from combined serious heart brain lung and kidney diseases or tumors;8.pregnant or lactating women;9. those who suffer from mental diseases or are incapable of cooperation. Those who are mentally ill or unable to cooperate.

Design outcomes

Primary

MeasureTime frame
transient elastography;AFP;Liver function;Serum proteomic indicators;Objectify tongue pulse and eye information;Serum liver fibrosis indicators;echocardiography;

Secondary

MeasureTime frame
Blood clotting time;

Countries

China

Contacts

Public ContactLi Jike

Chengdu Public Health Clinical Medical Center

lijikeke@163.com18080903650

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026