Amnestic mild cognitive impairment
Conditions
Interventions
Sponsors
Shenzhen traditional Chinese medicine hospital
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: Meet the aMCI diagnostic criteria: (Perterson 2004 criteria) : (1) Memory loss is the main complaint and it is confirmed by informed persons; (2) Objectively existing memory decline that is inconsistent with age; (3) General cognitive function is basically normal; (4) The ability of daily living is basically normal; (5) The degree of cognitive impairment is not sufficient to diagnose dementia. 2) There are symptoms of memory impairment and the course of the disease is >3 months; 3) The score of the Simple mental State Examination Scale (MMSE) is greater than or equal to 24 points; The overall score of the Clinical Dementia Rating Scale (CDR) was 0.5 and the memory domain was at least 0.5; 5) Age 50-75 years old primary school education or above; The ability of daily living was not affected and the scale (ADL) score was =26; 7) Right-handed Han nationality; 8) Willing to cooperate and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients who have received cognitive function related treatment within the past 1 month; Use of drugs that may affect cognitive function in the past 1 month including sedatives anti-anxiety drugs hypnotics and psychotropic drugs Drugs and cholinomimetic drugs; (3) Previous history of stroke brain tumor Parkinson's disease encephalitis epilepsy and brain trauma; (4) Obvious white matter lesions (Fazekas score = 3-6); 5) Patients with serious mental illness alcoholics drugs or other psychotropic drug abusers; 6) Severe hearing visual impairment and aphasia resulting in inability to achieve the assessment and failure to complete the test; A history of severe head trauma or other diseases involving the central nervous system affect the neuropsychological scale assessment Estimator; 8) have serious heart liver renal insufficiency and other systemic diseases; 9) Patients with contraindications of MRI or other subjects deemed unsuitable by the researchers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| AVLT-H;HAMD-17;MRI;CDR;OCT;MMSE;ADL; | — |
Countries
China
Contacts
Public ContactLiu Yongfeng
Shenzhen Traditional Chinese Medicine Hospital
Outcome results
None listed