non-erosive reflux disease
Conditions
Interventions
Group treated with the formula of Reducing Reversal and Promoting Viscera placebo:Treating with the formula of Reducing Reversal and Promoting Viscera placebo
Group treated with the formula of Reducing Reversal and Promoting Viscera :Treating with the formula of Reducing Reversal and Promoting Viscera
Sponsors
The Affiliated Hospital of Shanxi University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with nerdThe ages of between 18 and 75Chinese medicine diagnosed as spleen stomach dampness heat type 2.Negative diagnosis by endoscopyNot taking acid-suppressant 3.No abnormal esophageal resting pressureexcept for esophageal dyskinesia 4.Positive esophageal acid perfusion test acid perception hypersensitivity or reduced perception threshold for mechanical dilatation stimuli.
Exclusion criteria
Exclusion criteria: 1. Patients with serious primary diseases of the cardiovascular cerebrovascular hepatic renal endocrine hematopoietic systems and psychiatric disorders. 2. Tumors of the digestive tract; peptic ulcer; diseases of the liver gallbladder and pancreas cholecystectomy diabetes mellitus connective tissue diseases and other systemic diseases. 3. Women who are pregnant or breastfeeding; 4. People with allergies or multiple drug sensitivities; 5. Those with other digestive disorders other systemic diseases that can cause gastrointestinal symptoms such as irritable bowel syndrome (IBS); 6. Less than 20 years of age and more than 75 years of age.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of substance P\calcitonin gene related peptide positive nerve fibers;Ultrastructural changes in synaptic vesicles of nerve fibers ;Average optical density value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of the efficacy of clinical symptoms in Chinese medicine;Typical symptoms such as acid reflux heartburn post-chest pain and discomfort belching reflux etc.; | — |
Countries
China
Contacts
Public ContactPeifang Li
The Affiliated Hospital of Shanxi University of Chinese Medicine
Outcome results
None listed