Metabolic-associated fatty Liver disease
Conditions
Interventions
Chinese medicine fasting therapy group:Chinese medicine fasting therapy
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-70 years old (inclusive) gender is not limited; 2) Meet the western medical diagnostic criteria of MAFLD; 3)Patients agree to join this clinical study voluntarily sign an informed consent form and agree to participate in all visits examinations and treatments according to the requirements of the study protocol.
Exclusion criteria
Exclusion criteria: 1) Other causes of hepatobiliary disease suspected by history and laboratory testing including but not limited to: hepatitis B or C virus infection alcoholic liver disease drug-induced liver disease autoimmune hepatitis cirrhosis of the liver primary sclerosing cholangitis Wilson's disease al-antitrypsin deficiency and hepatocellular carcinoma (or a family history of hepatocellular carcinoma); (ii) Clinical evidence suggesting the presence of cirrhosis or hepatic decompensation; 3) Severe renal insufficiency defined as blood creatinine (Scr) =178 µmol/L or glomerular filtration rate (eGFR) <60 ml/min; 4)Patients with combined cardiovascular cerebrovascular urinary and hematopoietic serious primary diseases extensive tumors or metastatic tumors other serious comorbidities or psychiatric disorders; 5) Patients with combined type 1 diabetes mellitus or type 2 diabetes mellitus with advanced islet failure or previous severe hypoglycemic events; (vi) Combined thyroid disease including hyperthyroidism hypothyroidism and subclinical hypothyroidism; (vii) Combined severe chronic infectious diseases such as terminal tuberculosis open tuberculosis and AIDS; (8) Pregnant and breastfeeding women and women with pregnancy potential who refuse to maintain investigator-approved contraception throughout the study; 9) Participation in other clinical trials in the last 3 months; 10) Those who are unable to perform the lifestyle intervention as prescribed by their physician; 11) Other conditions deemed by the investigator to exist that make participation in this study inappropriate such as ulcer patients with severe gastric bleeding paralysis due to stroke and during glucocorticoid administration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FibroScan; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body measurement indicators;Serum high sensitivity C-reactive protein;Blood routine;Lipid metabolism;adipocytokine;Insulin resistance index;Liver and kidney function;FPG;Vitamin D; | — |
Countries
China
Contacts
Public ContactYueqiu Gao
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed