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To explore the biological mechanism of abnormal bone metabolism in schizophrenic patients with kidney Yang deficiency syndrome differentiation based on "kidney-brain-bone" cohort

To explore the biological mechanism of abnormal bone metabolism in schizophrenic patients with kidney Yang deficiency syndrome differentiation based on "kidney-brain-bone" cohort

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2025000373
Enrollment
Unknown
Registered
2025-02-20
Start date
2025-02-28
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Interventions

SCZ with abnormal BMD:None
SCZ with normal BMD:None

Sponsors

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.According to the diagnostic criteria of SCZ in the 10th edition of the International Classification of Diseases (ICD-100) patients were diagnosed as SCZ by psychiatrists 2. Age >=18 years old. 3.Receiving routine psychiatric treatment and management during the hospital maintenance period and receiving antipsychotic drugs during the continuous hospitalization for more than 1 year. 4.I can cooperate with the investigation smoothly. I and my family members agree to participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1.Unable to cooperate with the investigators due to the change of the patient's condition and great mood fluctuations during the study; 2.Affected lumbar spine and femoral neck bone mineral density by DXA evaluation; 3.Complicated with severe endocrine diseases; 4.Substance or alcohol dependent patients; 5.Pregnant and lactating women; 6.Those who cannot cooperate with the study or withdraw from the study.

Design outcomes

Primary

MeasureTime frame
Bone mineral density;

Secondary

MeasureTime frame
Bone metabolism index;Blood routine index;visual analogue scale;IOF Osteoporosis Risk Test Sheet;Targeting metabolomics;FRAX;Calcium and phosphorus metabolism index;Metagenomic sequencing;Physical examination index;Positive and negative symptom scale;

Countries

China

Contacts

Public ContactYongjun Wang

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

wangyongjun@shutcm.edu.cn+86 135 8580 2162

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026