Coronary microcirculation disorder
Conditions
Interventions
Test group:Huoxue Wentong Formula Combined with Basic Treatment
Control group:Blood activating and warming formula placebo plus basic treatment
Sponsors
Guang'anmen Hospital Chinese Academy of Chinese Medicine Science
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1) Meets the Western diagnostic criteria for primary stable microvascular angina; 2) Men or women aged 18-79 years old; 3) Traditional Chinese medicine syndrome differentiation conforms to the Yang deficiency and blood stasis syndrome; 4) Not taking traditional Chinese medicine within one week; 5) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) After PCI coronary artery bypass grafting and old myocardial infarction; 2) Heart muscle bridge; 3) The electrocardiogram shows ST elevation changes or coronary angiography shows coronary spasm; 4) Severe mitral valve disease dilated or hypertrophic cardiomyopathy myocarditis congenital heart disease; 5) Grade II or above atrioventricular block or severe arrhythmia; 6) Has non ischemic chest pain; 7) Cardiac function level III-IV (NYHA); 8) Left ventricular ejection fraction<50%; 9) Unable to simultaneously complete coronary angiography/coronary CTA and transthoracic Doppler echocardiography; 10) Having severe chronic obstructive pulmonary disease (such as asthma bronchiectasis emphysema pulmonary fibrosis etc.); 11) Suffering from acute pulmonary embolism or acute cerebral infarction; 12) Systemic hypotension (systolic blood pressure<90mmHg); 13) Has immune system diseases such as vasculitis; 14) Having mental illnesses; 15) Performing major surgical procedures in the past 3 months; 16) Pregnant pregnant or lactating women; 17) Decreased cognitive ability that prevents them from taking medication or completing laboratory tests as required by the experiment; Cancer patients or those with an expected lifespan of less than 4 years; 18) Patients with abnormal liver function and renal insufficiency (blood creatinine and urea nitrogen exceeding 1.2 times the normal range); 19) Individuals who are allergic to relevant drugs and have an allergic constitution.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single-Photon Emission Computed TomographySPECT;CFR; | — |
Secondary
| Measure | Time frame |
|---|---|
| SAQ;Cardiopulmonary Exercise TestingCPX;Scoring of Traditional Chinese Medicine Four Diagnostic Information; | — |
Countries
China
Contacts
Public ContactXiong Xingjiang
Guang'anmen Hospital Chinese Academy of Chinese Medicine Science
Outcome results
None listed