Pre-asthma
Conditions
Interventions
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Pre-asthma (1) Age= 18 years old male or female; (2) meet the diagnostic criteria for pre-asthma; (3) The patient is informed and signs the informed consent form. Mild asthma: (1) Age= 18 years old male or female; (2) meet the diagnostic criteria for mild; (3) The patient is informed and signs the informed consent form. Healthy Volunteers: (1) Age= 18 years old male or female; (2) No obvious abnormalities were found in the physical examination in the past year; (3) The patient is informed and signs the informed consent form.
Exclusion criteria
Exclusion criteria: Pre-asthma (1) Previous diagnosis of asthma; (2) Combined with chronic obstructive pulmonary disease bronchiectasis interstitial lung disease obstructive sleep apnea syndrome pulmonary malignancy active tuberculosis and other diseases; (3) Acute upper respiratory tract infection or pneumonia has been found in the past 1 month; (4) Severe cardiovascular and cerebrovascular diseases (including malignant arrhythmia acute myocardial infarction cardiac function grade 4 acute stroke etc.) and hematological diseases; (5) Combined with severe liver and kidney diseases including decompensated liver cirrhosis hemorrhage caused by portal hypertension or portal varices renal dialysis etc.; (6) Combined immunodeficiency such as malignant tumors organ/bone marrow transplantation HIV infection; (7) Those with mental disorders or cognitive disabilities. Mild asthma: (1) Combined with chronic obstructive pulmonary disease bronchiectasis interstitial lung disease obstructive sleep apnea syndrome pulmonary malignancy active tuberculosis and other diseases; (2) Severe cardiovascular and cerebrovascular diseases (including malignant arrhythmia acute myocardial infarction grade 4 cardiac function acute stroke etc.) and hematological diseases; (3) Combined with severe liver and kidney diseases including decompensated liver cirrhosis hemorrhage caused by portal hypertension or portal varices renal dialysis etc.; (4) Immunodeficiency such as malignant tumors organ/bone marrow transplantation HIV infection; (5) Those with mental disorders or cognitive disabilities. Healthy Volunteers: (1) Previous diagnosis of asthma; (2) Combined with chronic obstructive pulmonary disease bronchiectasis interstitial lung disease obstructive sleep apnea syndrome pulmonary malignancy active tuberculosis and other diseases; (3) Patients with allergic rhinitis eczema urticaria atopic dermatitis allergic conjunctivitis and other allergic diseases; (4) History of drug or food allergies in the past; (5) Acute upper respiratory tract infection or pneumonia has been found in the past 1 month; (6) Those with a history of smoking or lung-related surgeries; (7) Patients with serious primary diseases or malignant tumors of other organs (such as heart brain liver kidney etc.); (8) Patients with immune-related diseases such as systemic lupus erythematosus Sjögren's syndrome rheumatoid arthritis etc.; (9) Those with mental disorders or cognitive disabilities;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Distribution and changes of TCM syndromes;Annual rate of decline in peak and trough values of FEV1 and FVC in lung function;Change in FeNO value;Negative rate of bronchial dilation test;Demographic characteristics of patients with pre-asthma;Positive rate of bronchial dilation test;The distribution and change of TCM constitution assessment;Negative rate of bronchial provocation test;Incidence of exacerbations;Positive rate of bronchial provocation test;Valleys and peak changes of FEV1 FVC FEV1/FVC MMEF FEF50 FEF75;Change in Cough Degree Score (CET).;Distribution and change of TCM wet syndrome points;Asthma control scores including changes in ACT and ACQ; | — |
Countries
China
Contacts
Public ContactYuanbin Chen
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed