Chronic kidney disease
Conditions
Interventions
Intervention group:Externally applie "Hefuzhiyang lotion"
control group:Externally applie placebo
Sponsors
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for CKD stage 5 under the American Initiative for Quality in Prognosis of Kidney Disease (K/DOQI) clinical guidelines; (2) meet the diagnostic criteria for uremic pruritus; (3) Regular hemodialysis treatment for = 3 months; (4) Age 18-70 years old; (5) The condition was stable and the adequacy of dialysis before inclusion was included KT/V=1.2; (6) Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Previously diagnosed primary skin diseases such as atopic dermatitis chronic eczema drug eruption psoriasis neurodermatitis etc.; (2) Those who are known to be allergic to any of the components of the test drug; (3) Those with severe skin trauma ulceration infection etc. which are not suitable for external application of traditional Chinese medicine; (4) Those who have used antibiotics anti-allergic drugs analgesics dextran and other drugs or immunosuppressants and other traditional Chinese medicine preparations for the treatment of itchy skin within 1 month; (5) Patients with severe hypertension (systolic blood pressure > 180 and/or diastolic blood pressure >110mmHg) acute cerebrovascular accident severe heart disease severe anemia (Hb<60g/L) and acute cardiac insufficiency; (6) Those who have mental disorders cognitive disorders and other reasons that cannot cooperate with the diagnosis and treatment and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pruritus Visual Analogue Index VAS score;Dermatology Life Quality Index(DLQI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin barrier function test (stratum corneum water content and transdermal water loss);Serum uric acid;haemoglobin;Skin microbiota assay (16srRNA sequencing);Serum phosphorus;Serum total protein;Parathyroid hormone;Dialysis Effectiveness Index;Serum potassium;14-item uremia pruritus score in dialysis patients;Serum magnesium;Kidney Disease Quality of Life Qustionnaire(KDQOL-36TM);Serum albumin; | — |
Countries
China
Contacts
Public ContactLu Peng
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed