Acute postoperative pain
Conditions
Interventions
:Adenosine injection with 0.2mg(1ml) into the bilateral Zusanliacupoint of a single acupoint 10 minutes before anesthesia induction
control group:Administing 0.9% sodium chloride injection(1ml) per acupoint at both Zusanli acupoints 10 minutes before anesthesia induction
Sponsors
Shanghai Fourth People's Hospital affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) 18 years old= age = 75 years old 2) Patients proposed for laparoscopic cholecystectomy; 3)BMI of 18-30 kg/m^2; 4) ASA classification I to III; 5) Signing of informed consent Voluntarily.
Exclusion criteria
Exclusion criteria: 1). Second or third degree atrioventricular block sick sinus node syndrome (except patients with artificial pacemakers) ; 2). Patients with pulmonary disease with bronchial stenosis or bronchospasm (such as asthma); 3). Patients with hypersensitivity to adenosine; 4). Persons with communication disorders that prevent them from cooperating with the researcher such as language comprehension disorders psychiatric disorders; 5). Those who have had a heart attack or cerebral infarction within six months; 6). Pregnant or lactating women; 7). Infection at the acupuncture point injection site; 8) History of analgesic medication for a continuous period of 3 months prior to enrollment; 9.) Long-term use of ß blockers; 10).Other conditions that considered inappropriate for inclusion by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first salvage analgesia;Dose and frequency of salvage analgesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complications associated with acupoint injections;Time of first exhaust;Time of first bowel;Intraoperative sufentanil and remifentanil dosage;Incidence of nausea and vomiting;Intraoperative vital signs;Blood interleukin-18 concentration at 6h postoperatively;Campbell Sleep Scale score on the evening of the operating day;Patient Satisfaction Score;Pain VAS score; | — |
Countries
China
Contacts
Public ContactGuozhong Chen
Shanghai Fourth People's Hospital affiliated to Tongji University
Outcome results
None listed