sarcopenia
Conditions
Interventions
Exercise combined with sham stimulation group:Baduanjin combined with resistance exercise for 35 minutes each time
Sham stimulation will be performed with an "8" shaped coil placed at 90° on the scalp surface of the M1 region bilaterally. Stimulation parameters will be 10 Hz, 90% movement threshold (RMT), 2000 pul
Exercise combined with repetitive transcranial magnetic stimulation group:Baduanjin combined with resistance exercise for 35 minutes each time
transcranial magnetic stimulation of the bilateral motor cortex (M1), stimulation parameters of 10 Hz, 90% motor threshold (RMT), 2000 pulses (2 seconds × 100 columns, interval of 10 seconds), each in
control group: Sham stimulation will be performed with an "8" shaped coil placed at 90° on the scalp surface of the M1 region bilaterally. Stimulation parameters will be 10 Hz, 90% movement threshold
Sponsors
Chongming Hospital Affiliated to Shanghai Health Medical College
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age = 60 years; 2) Meet the diagnostic criteria for sarcopenia in the Asian Working Group on Sarcopenia (AWGS) 2019: measurement of limb skeletal muscle mass index (ASMI) (<7.0 kg/m2 for men; <5.7 kg/m2 for women) and grip strength (<28 kg and below for men; <18 kg for women) and/or 6-meter walking speed (<1 m/s) by bioelectrical impedance analyzer (BIA); and 3) Meet the diagnostic criteria for MCI in the 2024 Chinese Expert Consensus on the Diagnosis and Treatment of Mild Cognitive Impairment of Alzheimer's Disease Origin: subjective cognitive decline abnormalities in objective cognitive tests (Montreal Cognitive Assessment Scale (MoCA) scores <26 and Brief Mental State Examination (MMSE) scores <27) and intact daily functioning; and do not meet the diagnostic criteria for dementia; 4) Irregular exercise habits (regular exercise is defined as at least 20 minutes of vigorous exercise on at least 3 days per week or at least 30 minutes of moderate-intensity exercise on at least 5 days per week); 5) Suitability for transcranial magnetic stimulation: no metal implants (e.g. brain pacemakers) cardiac pacemakers or other contraindications affecting transcranial magnetic stimulation; scalp is suitable for placement of transcranial magnetic devices and there is no obvious excessive scalp thickness or excess fat; 6)Voluntary participation in this study and ability to complete the intervention and sign the informed consent form as required.
Exclusion criteria
Exclusion criteria: 1)Presence of severe cognitive impairment mental illness hearing impairment or visual impairment that prevents cooperation with the study; 2)A definite diagnosis of stroke history of traumatic brain injury epilepsy brain tumor or other brain disease; 3)Current major depression schizophrenia or other serious mental illness; 4) Presence of serious physical illness: uncontrolled hypertension (systolic blood pressure >200 mmHg or diastolic blood pressure >110 mmHg) cardiac arrhythmia or serious cardiovascular disease (e.g. stroke acute myocardial infarction angina pectoris uncontrolled ventricular tachycardia) moderate or severe chronic obstructive pulmonary disease (COPD); 5) Severe rash infection or inability to place fNIRS or rTMS devices on the scalp; 6)Regular use of medications that may interfere with cognitive function (e.g. antipsychotics high-dose glucocorticoids) or motor function (e.g. antiplatelet agents analgesics or anticoagulants) within the past 3 months; 7) Presence of movement disorders: absolute contraindications to exercise (e.g. deep vein thrombosis and/or coagulation disorders) musculoskeletal disorders (e.g. fractures dislocations) infectious skin diseases unhealed wounds or ulcers disabilities (e.g. loss of hand or foot).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;Knee extension strength; | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical performance;Muscle mass;Mini-Mental State Examination;Handgrip strength;Near-infrared assessment; | — |
Countries
China
Contacts
Public ContactChen Nan
Chongming Hospital Affiliated to Shanghai Health Medical College
Outcome results
None listed