carotid atherosclerosis with hyperlipidemia
Conditions
Interventions
Control group: Placebo of Huoxue Jiedu optimize recipe+Atorvastatin calcium tablets
Sponsors
Xiyuan Hospital China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) 40 years old = age =80 years old male or female are not limited; (2) Vascular ultrasound confirmed that it met the diagnostic criteria for carotid atherosclerosis carotid intimal thickness (IMT) = 1.0mm and carotid artery stenosis < 70% ; (3)Meet the diagnostic criteria for primary hyperlipidemia and meet any of the following: TC=5.2mmol/L; LDL-C=3.4mmol/L; TG=1.7mmol/L; (4)Traditional Chinese Medicine (TCM) syndrome differentiation belongs to the syndrome of blood stasis and toxin accumulation; (5)Not using lipid-lowering drugs/health products in the past 2 weeks; (6)Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1)Previously diagnosed coronary artery disease or comorbid uncontrolled hypertension (seated diastolic blood pressure =100 mmHg or systolic blood pressure =160 mmHg) or comorbid uncontrolled diabetes mellitus (glycated haemoglobin HbA1c =8.5%) or comorbid uncontrolled heart failure (NYHA classification =class III) and arrhythmias accompanied by clinical symptoms or haemodynamic disturbances; (2)Hyperlipidaemia induced by drugs (phenothiazines ß-blockers adrenocortical steroids and certain contraceptives etc.) or patients on hormones thyroxine therapeutics and other drugs affecting lipid metabolism; (3)Presence of a history of statin-associated liver damage and/or myopathy; (4)Patients with a combination of serious diseases of the lungs liver kidneys brain blood and other vital organs major infectious diseases severe metabolic/endocrine/electrolyte disorders active rheumatological-immunological disorders malignant tumours and psychiatric disorders (e.g. uncontrolled epilepsy depression mania schizophrenia etc); (5) Individuals who have experienced severe trauma or major surgery within the past six months, or have a tendency to bleed; (6) Pregnant and lactating women, as well as those planning to conceive within the past six months; (7) Individuals who are allergic to the experimental drug or its components; (8) Simultaneously participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carotid Intima-Media Thickness;LDL-C; | — |
Secondary
| Measure | Time frame |
|---|---|
| TG;Brachial-ankle pulse conduction velocity;Carotid artery plaque area;TC;HDL-C;Integral of TCM Syndrome; | — |
Countries
China
Contacts
Public ContactLizhi Li
Xiyuan Hospital Chinese Academy of Traditional Chinese Medicine
Outcome results
None listed