Small cell lung cancer
Conditions
Interventions
Treatment group:Shenling Baizhu powder +IP chemotherapy ± CRD Western standard treatment
Control group:IP protocol chemotherapy ± CRD Western standard treatment
Sponsors
Shenshan Medical Center Sun Yat-sen Memorial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Patients with extensive stage SCLC confirmed by pathology or cytology have at least one measurable lesion; 2)According to the CSCO guidelines chemotherapy regimen containing irinotecan was first used; 3)Age 18-80 years old (including 18 years old and 80 years old); 4) Physical condition (PS) score of 0-2 formulated by the American Eastern Cancer Collaborative Group (ECOG); 5) Expected survival =3 months; 6) Patients can understand the situation of this study can cooperate with doctors to evaluate diarrhea grading have good compliance and are willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients with primary malignant tumors of other systems or organs; 2) Confirmed combination of primary diseases causing diarrhea (such as acute and chronic enteritis inflammatory bowel disease etc.) radiation enteritis or long-term use of laxative drugs; 3) Received pelvic radiotherapy in the last 2 weeks; 4) Patients with severe uncontrolled organic disease or infection such as decompensated heart lung renal failure etc. resulting in inability to tolerate chemotherapy; 5) Pregnant or lactating women; 6) Participants in other clinical trials currently or within 4 weeks; 7)A significant neurological and psychiatric history including dementia that may affect comprehension and informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of diarrhea; | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of chemotherapy effect;Rate of change in chemotherapy plan;Degree of diarrhea; | — |
Countries
CHINA
Contacts
Public ContactXiao Haiwei
Shenshan Medical Center Sun Yat-sen Memorial Hospital
Outcome results
None listed