vertigo caused by chronic cerebral ischemia
Conditions
Interventions
Experimental group:Basic treatment + Qiangli Dingxuan tablets (5 tablets at a time 3 times a day)
Control group:Basic treatment + Qiangli Dingxuan tablets simulant(5 tablets at a time 3 times a day)
Sponsors
Dongfang HospitalBeijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1)Meet the diagnostic criteria of chronic cerebral ischemia in Western medicine and the diagnostic criteria of traditional Chinese medicine for vertigo; (2)Meet the syndrome differentiation criteria of traditional Chinese medicine for syndrome of ascendant hyperactivity of liver yang; (3)Presence of vertebrobasilar atherosclerosis stenosis or occlusive lesions confirmed by imaging(MRI or CTA) and cerebral hypoperfusion confirmed by imaging of brain perfusion(3D-ASL or CTP); (4)Age 40~85 years old(including endpoint value) male or female; (5)DHI score=60 points; (6)Understand and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1)Patients with vertigo caused by other diseases or orthostatic hypotension or other brain disorders are excluded; (2)Patients with severe primary diseases such as cardiovascular hepatic renal endocrine and hematopoietic systems or AST and ALT>1.5 times the upper limit of normal values or serum creatinine(Scr)>upper limit of normal values or patients with malignant tumors; (3)Those who have a history of anxiety or depression in the past or who have an anxiety or depression score of =11 on the Hospital Anxiety and Depression Scale(HADS); (4)Those who have intellectual/language impairment that make them unable to fill in the scale or record their own symptoms and are unable to cooperate or those who are unwilling to cooperate; (5)Those with allergies (such as allergies to two or more drugs and food) or allergies to strong dizzy tablets and the corresponding simulant-related ingredients; (6)Women of childbearing age are pregnant lactating have a birth plan during the study have a positive pregnancy test(urine HCG or blood HCG) or cannot take effective contraceptive measures during the test; (7)Those who are participating in or have participated in other clinical trials in the past 1 month; (8)Those who are considered by the investigator to be unsuitable to participate in this clinical trial for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Vertigo Impairment Scale(DHI)score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in TCM pattern scores;2h immediate dizziness relief rate;Changes in Vertigo VAS score;University of California Los Angeles Dizziness Questionnaire(UCLA-DQ);Frequency/duration of vertigo episodes; | — |
Countries
China
Contacts
Public ContactZhigang Chen
Dongfang HospitalBeijing University of Chinese Medicine
Outcome results
None listed