Cough-variant asthma
Conditions
Interventions
Sponsors
Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients with cough-variant asthma (all 5 of the following are eligible for inclusion in the study): 1) Meet the diagnostic criteria for CVA; 2) Age 18-60 years old; gender is not limited; right-handed; 3) Regular application of antiasthmatic therapeutic drugs (mainly bronchodilators and [or] glucocorticoids) for at least 4 weeks without complete symptomatic relief with a cough severity VAS score value of >30 mm; 4) Voluntarily participate in this trial and sign the informed consent; 5) No contraindications to NMR scanning such as metals in the body. Healthy volunteers (all 4 of the following can be included in the study): 1) People aged 40 years = age = 80 years male or female right-handed; 2) The lung function test is not abnormal and the ability of daily life is normal; 3) No contraindications for nuclear magnetic scanning such as metals in the body; 4) Have good compliance voluntary co-operation with the study and signed informed consent.
Exclusion criteria
Exclusion criteria: Patients meeting any 1 of the following were excluded: 1) Have a history of or been experiencing acute respiratory infections in the last 2 weeks such as colds/ pneumonia/ active tuberculosis; 2) Combined typical asthma COPD and other respiratory diseases that have symptoms such as shortness of breath in addition to cough as the main complaint; 3) Have infection or other focal injury multiple infarcts or infarcts located in areas of the cognitive control network or severe cerebral white matter lesions (Fazekas score =3) as suggested by MRI of the brain; 4) Have cancer mental illness cognitive dysfunction and hearing impairment that prevents normal communication; 5) Suffer from local skin lesions at acupoints such as burns/eczema/ ulcers/ frostbite breakouts/ coagulation disorders; 6) Women who are breastfeeding pregnant or preparing for pregnancy; 7) Patients within the last six months or who are participating in other clinical studies. Healthy volunteers (excluded if any 1 of the following is met): 1) People with claustrophobia; 2) Severe cranial anatomical asymmetry or definite lesions detected in the MRI scan; 3) Those who are participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cough evaluation test;Coughing frequency in 24h;Leicester cough questionnaire;Cough hypersensitivity questionnaire;Hamilton anxiety scale;Cough severity dairy;Peripheral blood eosinophil counts;Pittsburgh sleep quality index;Fractional exhaled nitric oxide;Hamilton depression scale; | — |
Countries
the People's Republic of China
Contacts
Public ContactLiang Fanrong
Chengdu University of Traditional Chinese Medicine
Outcome results
None listed