Post-stroke cognitive impairment
Conditions
Interventions
treatment group:"Yi Sui Xing Shen" Acupuncture Rehabilitation Treatment
Sponsors
Dongzhimen Hospital Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) One or more acute cerebrovascular disease (ischemic) events occurred within 3 to 14 days which can be clearly traced and cerebral infarction was diagnosed by CT or MRI; (2) Patients or family members subjectively reported cognitive decline after the stroke event with normal or mildly impaired daily living ability but the impaired daily living ability was not associated with motor/sensory symptoms caused by the stroke event. (3) Cognitive neuropsychological scale: MOCA17 points primary school >20 points middle school and above >24 points; (4) judged to be right-handed (EHI score > 40); (5) The age of onset is 18-80 years old gender and nationality are not limited; (6)NIHSS score < 20 points; (7) The subject gives informed consent and signs the informed consent voluntarily.
Exclusion criteria
Exclusion criteria: (1) Any known cognitive impairment including alcohol-induced cognitive impairment has been diagnosed before the onset of the stroke event; (2) Symptoms or manifestations that may affect the neuropsychological evaluation such as severe hearing speech or emotional disorders uncontrolled active mental illness and post-stroke physical disabilities that affect the psychological evaluation; (3) Patients with severe comorbidities such as severe cardiopulmonary dysfunction liver and kidney dysfunction and unstable vital signs; (4) Patients had been treated with cognitive enhancers and other anti-dementia agents including but not limited to cholinesterase inhibitors and non-competitive n-methyl-D-aspartate receptor antagonists within 1 month prior to the screening period; (5) Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment, MoCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Loewenstein occupational therapy cognitive assessment, LOTCA;rs-fMRI;task-fMRI;mini-mental state examination, MMSE;EEG;activity of daily living, ADL;event-related potential, ERP;Hamilton depression scale, HAMD;HamiltonAnxiety Scale, HAMA;Ischemic stroke syndrome factor diagnostic scale;DTI;Inflammatory serum biomarkers;HBV;HRV;3D-MRI;National Institutes of Health Stroke Scale, NIHSS;Serum biological indicators related to neural plasticity; | — |
Countries
China
Contacts
Public ContactJingling Chang
Xiamen Hospital of TCM.
Outcome results
None listed