IgA nephropathy
Conditions
Interventions
TCM group:Yiqi Jianpi Xiaoyu Formula
Integrated Traditional Chinese and Western Medicine Group:Yiqi Jianpi Xiaoyu Formula combined with half-dose Compound a-Ketoacid Tablets
Western medicine group:Compound a-Ketoacid Tablets
Sponsors
The Third Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meetting the diagnostic criteria of CKD stage 3-4 of Western medicine and have not undergone renal replacement therapy;(2) CKD in line with TCM qi deficiency and stasis syndrome;(3) Aged 18~75 years old gender is not limited;(4) Agree to the treatment of this study join the management of chronic diseases and sign the informed consent form;(5) No other drug tests have been carried out in the past 3 months or have been effective drug washout period.
Exclusion criteria
Exclusion criteria: (1) Accompanied by severe organ lesions;(2) Allergy to or contraindication to the use of drugs involved in the study protocol;(3) Renal replacement therapy should be carried out immediately if renal failure or chronic renal failure with acute exacerbation is prepared or has been used for kidney transplantation;(4) hypercalcemia or amino acid metabolism disorder;(5) Pregnant or lactating women;(6) Have a history of mental illness or poor compliance with communication and cognitive dysfunction and cannot cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALA;Slope of eGFR;PA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of new cardiovascular events;UACR;SGA score;TCM syndrome score;Percentage of end-stage renal disease occurrence: eGFR <10mL/(min-1.73m²) or renal replacement therapy; | — |
Countries
China
Contacts
Public ContactLu Keda
The Third Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed