Sepsis-associated AGI
Conditions
Interventions
Observation group:none
Sponsors
Henan Provincial Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age ranges from 18 to 85 years old. 2. Meet the diagnostic criteria for both sepsis and acute gastrointestinal injury simultaneously. 2.1 Diagnostic criteria for sepsis Refer to the diagnostic criteria for sepsis in the "Chinese Guidelines for Emergency Treatment of Sepsis/Sepsis Shock 2018" (1) Infection or suspected infection Infection indicators: Confirmed or highly suspected infection should possess the following clinical features: 1) Fever (deep body temperature > 38.3°C) or hypothermia (deep body temperature 90 beats per minute or > 2 standard deviations of the normal heart rate for different ages; 3) Tachypnea respiratory rate > 30 breaths per minute. Infection can be determined if two or more of the above three items are met. (2) Change in SOFA score = 2 points Patients with infection or suspected infected sepsis can be diagnosed when the Sepsis-related Organ Failure Assessment (SOFA) score increases by = 2 points compared to the baseline. 2.2 Diagnostic criteria for acute gastrointestinal injury (AGI) Refer to the definition and grading criteria for acute gastrointestinal injury (AGI) formulated by the European Society of Intensive Care Medicine (ESICM) in 2012 (1) AGI grade I: It refers to partial impairment of gastrointestinal function characterized by being temporary and self-limiting. (2) AGI grade II: The digestive and absorptive functions of the gastrointestinal tract cannot meet the body's nutritional and fluid requirements. (3) AGI grade III: Gastrointestinal function is lost and remains ineffective after taking intervention measures (such as erythromycin postpyloric intubation etc.). (4) AGI grade IV: AGI progresses to a life-threatening factor accompanied by multiple organ failure and shock. 3. The acute onset course is within 3 days. 4. Informed consent must be signed by all cases before enrollment. 5. The case data are completely recorded. All of the above items must be met simultaneously to be included in this study.
Exclusion criteria
Exclusion criteria: (1) Patients with severe allergic constitution; (2) Patients with concurrent pregnancy; (3) ICU stay <7 days; (4) Patients with definite immunodeficiency diseases or other definite immunosuppressive conditions. Any one of these criteria is sufficient for exclusion from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SOFA score;APACHE-II score;Blood routine;C-reactive protein;Procalcitonin;Blood lipid; | — |
Secondary
| Measure | Time frame |
|---|---|
| proteomics;Non-targeted metabolomics;Targeting metabolomics; | — |
Countries
China
Contacts
Public ContactLihui Wang
Henan Provincial Traditional Chinese Medicine Hospital
Outcome results
None listed