persistent cervical high-risk HPV infection
Conditions
Sponsors
Obstetrics & Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1)age: 18-65 years non-pregnancy non-lactation sexual life history; 2) Patients diagnosed with cervical high-risk HPV positive infection for 6 months or more by HC2 test HPV subtype testing and PCR (i. e. the reporting interval between two high-risk HPV types is at least 6 months); 3) No fertility requirements in the past 7 months; 4) Newberg's liquid-based cytological test (TCT)or LCT test: no intraepithelial lesions or malignant lesions or inflammatory changes or ASC-US or LSIL have undergone histopathological examination results of inflammation and LSIL; 5) Patients who voluntarily join the clinical trial and actively cooperate with the follow-up and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1)allergy to matshen gel and its components; 2)Colposcopic histopathological examination of HSIL AIS and above lesions; 3)Non-menopausal patients with menstrual disorders who can not be used in normal cycles; 4)Using other drugs or immunosuppressive drugs for HPV infection for 3 months prior to enrollment; 5)The acute inflammation of the reproductive tract needs to be treated (bacterial vaginosis vulvovaginal pseudogenosis trichomonas vaginitis acute cervicitis etc.; 6)Combined with mental diseases or accompanied by important organ diseases or metabolic diseases; 7)Have bad life habits or recent exposure to toxic substances such as drugs. 8)Use of topical vaginal drugs such as antimicrobial drugs and lactobacillus preparations within 7 days before enrollment;9) in process with other clinical trial .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| he negative conversion rates of hr-HPV; | — |
Secondary
| Measure | Time frame |
|---|---|
| the negative conversion rates of hr-HPV subtypes;the negative conversion rates of hr-HPV subtypes;the negative conversion rates of hr-HPV;Alterations in vaginal microbiota 16S rRNA sequencing before and after treatment; | — |
Countries
China
Contacts
Public ContactLong Sui
0bstetrics & Gynecology Hospitalof Fudan University
Outcome results
None listed