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The mechanism of icariin regulating TWEAK/SIRT1 and promoting Shelterin complex mediated telomere protection in thin endometrium

The mechanism of icariin regulating TWEAK/SIRT1 and promoting Shelterin complex mediated telomere protection in thin endometrium

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2025000203
Enrollment
Unknown
Registered
2025-01-28
Start date
2025-01-28
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thin endometrium

Interventions

Normal endometrium group: none
thin endometrium group:none

Sponsors

shenzhen nanshan people hospital' hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: A menstrual flow less than 30 ml (according to menstrual bleeding chart method); B sex hormone levels were within normal range on the 2nd to 5th day of testing; C Hysteroscopy examination: On the 15th to 25th day of menstruation (25th to 30th day of menstrual cycle), the endometrium is smooth and thin, there is no adhesion.In the uterine cavity, and the opening of the fallopian tubes is clearly visible; Normal endometrium: Menstrual volume less than 30 ml, endometrial thickness = 7 mm, and the rests are the same as above. D Measurement of endometrial thickness using transvaginal color Doppler ultrasound (TV-CDU): endometrial thickness during secretion phase<7 mm;

Exclusion criteria

Exclusion criteria: Patients who have not signed informed consent; Internal diseases such as diabetes, tuberculosis, thyroid, adrenal and other endocrine diseases; Serious infectious diseases or organ disease; Diseases such as tumors that may cause systemic effects.

Design outcomes

Primary

MeasureTime frame
Expression of tumor necrosis factor-like weak inducer of apoptosis;Expression of Shelterin complex;Expression of Sirtuin 1;Expression of nuclear factor erythroid 2-like-2;

Secondary

MeasureTime frame
telomere length;

Countries

China

Contacts

Public ContactLe ai wen

shenzhen nanshan people hospital' hospital

leaiwen@126.com+8618038090785

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026