Kidney Deficiency and Blood Stasis Type Immune-Related Recurrent Spontaneous Abortion
Conditions
Interventions
control group:After being included in this study participants began to take low molecular weight heparin: Fraxiparine 0.4ml subcutaneous injection once daily (qd) from the 5th week of pregnancy until
observation group:After being included in this study participants began taking Anzi Diaochong Tang starting from the 5th week of pregnancy until the end of the 11th week then discontinued the medicati
Sponsors
Shenzhen Maternity & Child Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for immune-related recurrent miscarriage and is identified as having kidney deficiency and blood stasis syndrome 2. The current pregnancy is either natural conception or resulting from IVF-ET (In Vitro Fertilization-Embryo Transfer) 3. Age is between 20 and 40 years old 4. FSH (Follicle Stimulating Hormone) level is =10 mIU/L during the follicular phase 5. Immunological factors in RSA (Recurrent Spontaneous Abortion) are either autoimmune or allogeneic 6. Have signed an informed consent form 7. Are capable of stable follow-up 8. Are willing to accept treatment with traditional Chinese medicine or immunosuppressive agents
Exclusion criteria
Exclusion criteria: 1. Combined with uterine structural abnormalities congenital pre-thrombotic state and endocrine dysfunction. 2. Those with a history of severe drug allergies. 3. With genetic factors such as recurrent miscarriage caused by chromosomal abnormalities in one of the spouses. 4. Recurrent miscarriage caused by infectious factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Human Chorionic Gonadotropin;Tolerogenic Dendritic Cells (tolDCs) Detection;Progesterone;CD86 molecule detection;Forkhead box P3;CD83 molecule detection;Estradiol;Transforming Growth Factor-beta;Tumor Necrosis Factor-alpha;FOXP3+ Regulatory T Cell Detection;CD80 molecule detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunoglobulin A;Complement 4;Rheumatoid factor;Total T cells (CD3+);Anti-Cardiolipin Antibody IgG;Anti-beta 2 Glycoprotein I IgG;Anti-RNP70 IgG;Protein S;Activated Partial Thromboplastin Time;CD3+CD4+ T cells;Anti-Nuclear Antibody;C-reactive protein;D-Dimer;Immunoglobulin G;Fibrinogen;Prothrombin Time;Complement 3;anti-SSB antibody;CD4/CD8 Ratio;Anti-beta 2 Glycoprotein I IgA;Anti-beta 2 Glycoprotein I IgM;CD3+CD8+ T cells;Homocysteine;B-lymphocytes (CD19+);Protein C;Anti-Streptolysin O;Natural killer (CD16+56+, CD3-);Anti-Cardiolipin Antibody IgM;Anti-Cardiolipin Antibody IgA;Thrombin Time;Anti-double stranded DNA antibody, IgG;Immunoglobulin M;Anti-Smith (Sm) Antibody, IgG;anti-SSA antibody; | — |
Countries
China
Contacts
Public ContactMa Fei
Shenzhen Maternity & Child Healthcare Hospital
Outcome results
None listed