rheumatoid arthritis
Conditions
Interventions
Experimental group:Basic western medicine treatment plus Bushen Jiedu Tongluo Decoction Granule One dose a day two times a day
control group:Basic western medicine treatment plus placebo Granule One dose a day, two times a day
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. According to the diagnostic criteria of RA it is in accordance with the diagnostic criteria of RA in active stage in accordance with the diagnostic criteria of traditional Chinese medicine; 2. Patients aged 18-80 years old; 3. Patients receiving hormone therapy should have a stable dosage of medication for at least 30 days before entering the trial and remain unchanged throughout subsequent treatments. Patients who receive other DMARDs must interrupt other DMARDs for at least 30 days; 4. Sign the informed consent form for entering clinical research.
Exclusion criteria
Exclusion criteria: 1. Those who do not meet the above inclusion criteria; 2. Pregnant lactating women or patients who are planning to give birth recently; 3. Individuals who are allergic to the experimental drug or have an allergic constitution; 4. Patients with severe primary diseases such as heart liver kidney brain endocrine system and hematopoietic system as well as psychiatric patients; 5. Patients with interstitial lung disease; Patients with severe elevation of liver enzymes (ALT = 3 times normal); Patients with renal dysfunction (eGFR<90ml/min/1.73m2); 6. Overlap with other rheumatic diseases such as systemic lupus erythematosus Sjogren's syndrome myositis etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DAS28-ESR; | — |
Secondary
| Measure | Time frame |
|---|---|
| ACR20/50/70 reaction standard;HIF-1a;RAPID3;Ultrasound Imaging Score(US7);MIF;SHARP Score;C-reactive protein;TCM syndrome curative effect score;Erythrocyte sedimentation rate;HAQ Disability Index, HAQ-DI;MMP-2;ICAM-1;VAS test;CD147;VCAM-1; | — |
Countries
China
Contacts
Public ContactHe Yikun
Shuguang Hospital Affiliated to Shanghai University of traditional Chinese Medicine
Outcome results
None listed