Subjective Cognitive Decline
Conditions
Interventions
sham-taVNS Group:Transcutaneous auricular non-vagal nerve stimulation
Sponsors
Dongzhimen Hospital Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for subjective cognitive decline. 2.Subjective Cognitive Decline Questionnaire (SCD-Q) score > 5. 3.Memory decline is perceived subjectively rather than other cognitive functions. 4.Onset time = 5 years. 5.Age 55 - 80 years old with no less than 6 years of formal education no gender restriction right - handed. 6.No intake of any drugs for improving cognitive function (such as donepezil memantine rivastigmine galantamine huperzine compound cistanche intellectual capsule etc.) in the past 1 month and no acupuncture or neuromodulation treatment received. 7.Able to accept auricular acupoint electrical stimulation treatment and MRI scanning. 8.Normal corrected vision and hearing capable of completing neuropsychological cognitive assessment. 9.Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with mild cognitive impairment prodromal dementia or dementia. 2.Individuals whose cognitive decline can be explained by psychiatric disorders or neurological diseases (excluding Alzheimer's disease) internal medicine diseases drug side effects etc. 3.Patients with severe neuropsychiatric disorders serious heart lung liver kidney or hematopoietic system diseases and malignant tumors. 4.Individuals with contraindications for MRI examination such as metal teeth pacemakers stents or claustrophobia etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory Verbal Learning Test of Huashan version; | — |
Secondary
| Measure | Time frame |
|---|---|
| Shape Trails Test A and B;Pittsburgh Sleep Quality Index;Subjective cognitive Decline questionnaire scale-9;fMRI;Montreal Cognitive Assessment Basic;Geriatric depression scale;Verbal fluency test;Stroop;sMRI; | — |
Countries
China
Contacts
Public ContactShuai Zhang
Dongzhimen Hospital Beijing University of Chinese Medicine
Outcome results
None listed