Skin reactions related to tumor immunotherapy
Conditions
Interventions
control group:Basic treatment+ "Reconcile skin Antipruritic Lotion" placebo
test group: Basic treatment+ "Reconcile skin Antipruritic Lotion"
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with advanced malignant tumors diagnosed clinically or pathologically; 2. Currently using Trastuzumab for treatment; 3. Age = 18 years old = 80 years old; 4. Prior to this experiment all indicators (blood routine /biochemistry/ urine routine etc.) were evaluated and found to be normal or clinically insignificant; 5. The evaluation criteria for irAEs on the skin are clear including clinical symptoms laboratory indicators or imaging evaluations. The rash grading is G1-G2; 6. Informed consent and voluntary participation of researchers.
Exclusion criteria
Exclusion criteria: 1. Severe heart liver kidney and other organic diseases as well as autoimmune diseases (blood creatinine clearance rate<30ml/min alanine aminotransferase = 2.5 times the upper limit of normal total bilirubin = 1.5 times the upper limit of normal; chronic heart failure heart function grade III or above); 2. Patients undergoing organ transplantation; 3. Adverse skin reactions caused by autoimmune skin diseases etc; (1) Serious heart liver kidney and other organic diseases as well as autoimmune diseases (blood creatinine clearance rate<30ml/min alanine aminotransferase = 2.5 times the upper limit of normal total bilirubin = 1.5 times the upper limit of normal; chronic heart failure heart function grade III or above); 4. Patients with severe mental illness; 5. Pregnant and lactating women; 6. Allergic constitution patients; 7. Patients who are currently participating in other similar clinical trials; 8.Individuals with cognitive comprehension and language expression impairments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Overall Impression Scale;Traditional Chinese Medicine Main Symptom Score;Dermatology Life Quality Index; | — |
Countries
China
Contacts
Public ContactGuiya Liao
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed