Elderly Heart Failure with Preserved Ejection Fraction (HFpEF) and Frailty
Conditions
Interventions
"Exposed group":On the basis of the control group an additional treatment of Yiqi Fumai Injection (manufactured by Tianjin Tasly-Tjq Pharmaceutical Co. Ltd. National Medical Products Administration Ap
"Non-exposed group":Based on the "2023 Chinese Expert Consensus on Diagnosis and Treatment of Heart Failure with Preserved Ejection Fraction (HFpEF)" and the "2022 Chinese Expert Consensus on Preventi
Sponsors
The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Meeting the diagnostic criteria for heart failure with preserved ejection fraction (HFpEF) and frailty (FRAIL scale score = 3); 2) Age between 60 and 90 years regardless of gender; 3) New York Heart Association (NYHA) functional classification of heart failure II to III; 4) Patients who have provided informed consent and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients with chronic heart failure who recently require instrumental therapy; 2) Patients with acute coronary syndrome (within 30 days) cardiogenic shock acute myocarditis uncontrolled hypertension (systolic blood pressure = 180mmHg and/or diastolic blood pressure = 110mmHg) uncontrollable malignant arrhythmia hypertrophic obstructive cardiomyopathy severe valvular heart disease requiring surgical treatment pulmonary embolism etc.; 3) Patients with severe hepatic and renal insufficiency; 4) Patients with severe anemia; 5) Patients with severe mental illness malignant tumors or other uncontrolled systemic diseases; 6) Patients who have participated in drug clinical trials in the past month; 7) Patients with suspected or confirmed allergies to the study drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6-minute walk distance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Kansas Heart Failure Questionnaire;NT-pro BNP/BNP;Frailty Index;E/e'; | — |
Countries
CHINA
Contacts
Public ContactLV Shichao
The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed